Gene
ebf1a
- ID
- ZDB-GENE-081028-51
- Name
- EBF transcription factor 1a
- Symbol
- ebf1a Nomenclature History
- Previous Names
-
- EBF1a
- sb:eu427
- si:ch73-38f1.1
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Is expressed in nervous system and neural tube. Orthologous to human EBF1 (EBF transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu427 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027550Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa35725 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35726 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018350 | Transcription factor COE, conserved site |
| Domain | IPR002909 | IPT domain |
| Domain | IPR032200 | Transcription factor COE, DNA-binding domain |
| Domain | IPR032201 | Transcription factor COE, helix-loop-helix domain |
| Domain | IPR038006 | Transcription factor COE, IPT domain |
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Domain Details Per Protein
| Protein | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Transcription factor COE | Transcription factor COE, conserved site | Transcription factor COE, DNA-binding domain | Transcription factor COE, DNA-binding domain superfamily | Transcription factor COE, helix-loop-helix domain | Transcription factor COE, IPT domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IWI1
|
591 | |||||||||
|
UniProtKB:A0A8M3AGT4
|
606 | |||||||||
|
UniProtKB:A0A8M6Z496
|
603 | |||||||||
|
UniProtKB:A0A8M6Z2R8
|
605 | |||||||||
|
UniProtKB:A0A8M3B0H5
|
604 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-38F1 | ZFIN Curated Data | |
| Contained in | BAC | CH73-153L23 | ZFIN Curated Data | |
| Contained in | BAC | CH73-242A13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-11L24 | ZFIN Curated Data | |
| Encodes | EST | eu427 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423970 (1) | |||
| Genomic | GenBank:CU012046 (1) | 130538 nt | ||
| Polypeptide | UniProtKB:A0A8M3AGT4 (1) | 606 aa |
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Taylor, R., Hamid, F., Fielding, T., Gordon, P.M., Maloney, M., Makeyev, E.V., Houart, C. (2022) Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS. Nature communications. 13:69946994
- Pradhan, S.J., Reddy, P.C., Smutny, M., Sharma, A., Sako, K., Oak, M.S., Shah, R., Pal, M., Deshpande, O., Dsilva, G., Tang, Y., Mishra, R., Deshpande, G., Giraldez, A.J., Sonawane, M., Heisenberg, C.P., Galande, S. (2021) Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. Nature communications. 12:6094
- Chi, Y., Huang, Z., Chen, Q., Xiong, X., Chen, K., Xu, J., Zhang, Y., Zhang, W. (2018) Loss of runx1 function results in B cell immunodeficiency but not T cell in adult zebrafish.. Open Biology. 8(7):
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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