Gene

vhll

ID
ZDB-GENE-081022-78
Name
von Hippel-Lindau tumor suppressor like
Symbol
vhll Nomenclature History
Previous Names
  • vll (1)
  • vhl-like (1)
  • zgc:194223
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to be involved in protein ubiquitination. Predicted to localize to VCB complex and nucleus. Human ortholog(s) of this gene implicated in several diseases, including pancreatic cancer (multiple); pheochromocytoma; polycythemia (multiple); renal cell carcinoma; and von Hippel-Lindau disease. Orthologous to human VHLL (VHL like) and VHL (von Hippel-Lindau tumor suppressor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Kim et al., 2020
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vhll Human Ortholog
No data available
Associated With vhll Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR022772 von Hippel-Lindau disease tumour suppressor, beta/alpha domain
Domain IPR024048 von Hippel-Lindau disease tumour suppressor, alpha domain
Domain IPR024053 von Hippel-Lindau disease tumour suppressor, beta domain
Homologous_superfamily IPR036208 VHL superfamily
Homologous_superfamily IPR037139 von Hippel-Lindau disease tumour suppressor, alpha domain superfamily
Homologous_superfamily IPR037140 von Hippel-Lindau disease tumour suppressor, beta domain superfamily
Domain Details Per Protein
Protein Length VHL superfamily von Hippel-Lindau disease tumour suppressor, alpha domain von Hippel-Lindau disease tumour suppressor, alpha domain superfamily von Hippel-Lindau disease tumour suppressor, beta/alpha domain von Hippel-Lindau disease tumour suppressor, beta domain von Hippel-Lindau disease tumour suppressor, beta domain superfamily
UniProtKB:B3DHE4 158
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA vhll-201 (1) Ensembl 540 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations