Gene

npm1b

ID

ZDB-GENE-080723-7

Name

nucleophosmin 1b

Symbol

npm1b Nomenclature History

Previous Names

npm4

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Acts upstream of or within hemopoiesis and regulation of apoptotic process. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in centrosome; cytoplasm; and nuclear lumen. Is expressed in several structures, including eye; fin bud; hematopoietic cell; hematopoietic stem cell; and somite. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Bolli et al., 2010

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Bolli et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With npm1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	Leukemia, acute myeloid, somatic	601626

Associated With npm1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR024057	Nucleoplasmin core domain
Domain	IPR032569	Nucleophosmin, C-terminal
Family	IPR004301	Nucleoplasmin family
Homologous_superfamily	IPR036824	Nucleoplasmin core domain superfamily