Gene
gabrr3a
- ID
- ZDB-GENE-080722-20
- Name
- gamma-aminobutyric acid type A receptor subunit rho3a
- Symbol
- gabrr3a Nomenclature History
- Previous Names
-
- zgc:194845
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable neurotransmitter receptor activity. Predicted to contribute to GABA-A receptor activity. Predicted to be involved in several processes, including chemical synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Predicted to act upstream of or within chloride transport. Predicted to be located in postsynaptic membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in eye; forebrain; and midbrain. Orthologous to human GABRR3 (gamma-aminobutyric acid type A receptor subunit rho3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17132 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
| Domain | IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
| Domain | IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
| Family | IPR006028 | Gamma-aminobutyric acid A receptor/Glycine receptor alpha |
| Family | IPR006201 | Neurotransmitter-gated ion-channel |
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Domain Details Per Protein
| Protein | Length | Gamma-aminobutyric acid A receptor/Glycine receptor alpha | Neuronal acetylcholine receptor | Neurotransmitter-gated ion-channel | Neurotransmitter-gated ion-channel, conserved site | Neurotransmitter-gated ion-channel ligand-binding domain | Neurotransmitter-gated ion-channel ligand-binding domain superfamily | Neurotransmitter-gated ion-channel transmembrane domain | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B3DIE5
|
472 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gabrr3a-201
(1)
|
Ensembl | 1,469 nt | ||
| ncRNA |
gabrr3a-002
(1)
|
Ensembl | 618 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-244C8 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-259J3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194845 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194850 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128760 (1) | 1469 nt | ||
| Genomic | GenBank:CR376845 (1) | 166564 nt | ||
| Polypeptide | UniProtKB:B3DIE5 (1) | 472 aa |
- Bampali, K., Koniuszewski, F., Vogel, F.D., Fabjan, J., Andronis, C., Lekka, E., Virvillis, V., Seidel, T., Delaunois, A., Royer, L., Rolf, M.G., Giuliano, C., Traebert, M., Roussignol, G., Fric-Bordat, M., Mazelin-Winum, L., Bryant, S.D., Langer, T., Ernst, M. (2023) GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach. Cell biology and toxicology. 39(6):2793-2819
- Sadamitsu, K., Shigemitsu, L., Suzuki, M., Ito, D., Kashima, M., Hirata, H. (2021) Characterization of zebrafish GABAA receptor subunits. Scientific Reports. 11:6242
- Probst, J., Kölker, S., Okun, J.G., Kumar, A., Gursky, E., Posset, R., Hoffmann, G.F., Peravali, R., Zielonka, M. (2020) Chronic hyperammonemia causes a hypoglutamatergic and hyperGABAergic metabolic state associated with neurobehavioral abnormalities in zebrafish larvae. Experimental neurology. 331:113330
- Monesson-Olson, B., McClain, J.J., Case, A.E., Dorman, H.E., Turkewitz, D.R., Steiner, A.B., Downes, G.B. (2018) Expression of the eight GABAA receptor α subunits in the developing zebrafish central nervous system. PLoS One. 13:e0196083
- Cocco, A., Carolina Rönnberg, A.M., Jin, Z., André, G.I., Vossen, L.E., Bhandage, A.K., Thörnqvist, P.O., Birnir, B., Winberg, S. (2017) Characterisation of the γ-aminobutyric acid signalling system in the zebrafish (Danio rerio Hamilton) central nervous system by reverse transcription quantitative polymerase chain reaction. Neuroscience. 343:300-321
- Raftery, T.D., Volz, D.C. (2015) Abamectin induces rapid and reversible hypoactivity within early zebrafish embryos. Neurotoxicology and teratology. 49:10-8
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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