Gene

mylk2

ID

ZDB-GENE-080616-2

Name

myosin light chain kinase 2

Symbol

mylk2 Nomenclature History

Previous Names

skeletal muscle MLCK (1)
skMLCK (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have myosin light chain kinase activity. Predicted to be involved in protein phosphorylation. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 1. Is expressed in heart. Orthologous to human MYLK2 (myosin light chain kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mylk2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypertrophic cardiomyopathy 1	Alliance	Cardiomyopathy, hypertrophic, 1, digenic	192600

Associated With mylk2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily