Gene
emilin3b
- ID
- ZDB-GENE-080612-3
- Name
- elastin microfibril interfacer 3b
- Symbol
- emilin3b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Acts upstream of or within muscle cell development; notochord morphogenesis; and regulation of smoothened signaling pathway. Is expressed in chordo neural hinge; floor plate; hypochord; and pharyngeal arch 3-7 skeleton.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa45784 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005161925 (1) | 5354 nt | ||
| Genomic | GenBank:FQ377965 (1) | 23597 nt | ||
| Polypeptide | RefSeq:XP_005161982 (1) |
- El-Brolosy, M.A., Kontarakis, Z., Rossi, A., Kuenne, C., Günther, S., Fukuda, N., Kikhi, K., Boezio, G.L.M., Takacs, C.M., Lai, S.L., Fukuda, R., Gerri, C., Giraldez, A.J., Stainier, D.Y.R. (2019) Genetic compensation triggered by mutant mRNA degradation. Nature. 568(7751):193-197
- Rossi, A., Kontarakis, Z., Gerri, C., Nolte, H., Hölper, S., Krüger, M., Stainier, D.Y. (2015) Genetic compensation induced by deleterious mutations but not gene knockdowns. Nature. 524(7564):230-3
- Corallo, D., Schiavinato, A., Trapani, V., Moro, E., Argenton, F., and Bonaldo, P. (2013) Emilin3 is required for notochord sheath integrity and interacts with Scube2 to regulate notochord-derived Hedgehog signals. Development (Cambridge, England). 140(22):4594-4601
- Hu, Y.L., Pan, X.M., Xiang, L.X., and Shao, J.Z. (2010) Characterization of C1Q in teleosts: insight into the molecular and functional evolution of C1Q family and classical pathway. The Journal of biological chemistry. 285(37):28777-28786
- Milanetto, M., Tiso, N., Braghetta, P., Volpin, D., Argenton, F., and Bonaldo, P. (2008) Emilin genes are duplicated and dynamically expressed during zebrafish embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(1):222-232
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