Gene

myo9aa

ID

ZDB-GENE-080424-5

Name

myosin IXAa

Symbol

myo9aa Nomenclature History

Previous Names

myo9a1 (1)
myo9al1

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable actin filament binding activity. Acts upstream of or within axon extension; neuromuscular junction development, skeletal muscle fiber; and swimming behavior. Predicted to be located in several cellular components, including cytoplasm; growth cone; and synapse. Predicted to be part of myosin complex. Predicted to be active in axonal growth cone. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to human MYO9A (myosin IXA).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from O'Connor et al., 2016

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from O'Connor et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myo9aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Myasthenic syndrome, congenital, 24, presynaptic	618198

Associated With myo9aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR000159	Ras-associating domain
Domain	IPR000198	Rho GTPase-activating protein domain
Domain	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain	IPR028558	Unconventional myosin-IXa, Ras-associating domain
Domain	IPR036023	Class IX myosin, motor domain
Family	IPR046987	Unconventional class IX myosin
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily
Homologous_superfamily	IPR046349	C1-like domain superfamily

Domain Details Per Protein

Protein	Length	C1-like domain superfamily	Class IX myosin, motor domain	IQ motif, EF-hand binding site	Kinesin motor domain superfamily	P-loop containing nucleoside triphosphate hydrolase	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Ras-associating domain	Rho GTPase-activating protein domain	Rho GTPase activation protein	Ubiquitin-like domain superfamily	Unconventional class IX myosin	Unconventional myosin-IXa, Ras-associating domain
UniProtKB:A0A8M3BBC1 InterPro	2566
UniProtKB:A0A8M3AUN4 InterPro	2572
UniProtKB:A0A8M9Q2V1 InterPro	2524
UniProtKB:E7EZG2 InterPro	2522
UniProtKB:A0A8M9Q8Z2 InterPro	2571
UniProtKB:A0A8M9PQ71 InterPro	2546
UniProtKB:A0A8M9Q2U6 InterPro	2572
UniProtKB:A0A8M9QI24 InterPro	2590
UniProtKB:A0A8M9QD37 InterPro	2547
UniProtKB:A0A8M9QI33 InterPro	2540
UniProtKB:A0A8M9PQ66 InterPro	2584
UniProtKB:A0A8M9Q8Z6 InterPro	2509

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	myo9aa-201 (1) Ensembl	Ensembl		7,569 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations