Gene

ep300a

ID

ZDB-GENE-080403-16

Name

E1A binding protein p300 a

Symbol

ep300a Nomenclature History

Previous Names

EP300b1 (1)
EP300b2 (1)
P300-A (1)
gb:dq017643
im:7158255

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Exhibits histone acetyltransferase activity. Involved in embryonic cranial skeleton morphogenesis; heart looping; and pectoral fin development. Predicted to localize to histone acetyltransferase complex. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Is expressed in blastoderm; blastomere; brain; intestinal bulb; and liver. Orthologous to human EP300 (E1A binding protein p300).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7158255 (1 image)
dq017643 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ep300a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
colorectal cancer	Alliance	Colorectal cancer, somatic	114500
Rubinstein-Taybi syndrome	Alliance	Rubinstein-Taybi syndrome 2	613684
		Menke-Hennekam syndrome 2	618333

Associated With ep300a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018359	Bromodomain, conserved site
Domain	IPR000197	Zinc finger, TAZ-type
Domain	IPR000433	Zinc finger, ZZ-type
Domain	IPR001487	Bromodomain
Domain	IPR003101	Coactivator CBP, KIX domain
Domain	IPR010303	CREB-binding protein/p300, atypical RING domain
Domain	IPR014744	Nuclear receptor coactivator, CREB-bp-like, interlocking
Domain	IPR031162	CBP/p300-type histone acetyltransferase domain
Family	IPR013178	Histone acetyltransferase Rtt109/CBP
Homologous_superfamily	IPR009110	Nuclear receptor coactivator, interlocking
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR035898	TAZ domain superfamily
Homologous_superfamily	IPR036427	Bromodomain-like superfamily
Homologous_superfamily	IPR036529	Coactivator CBP, KIX domain superfamily
Homologous_superfamily	IPR037073	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily
Homologous_superfamily	IPR038547	CBP/p300, atypical RING domain superfamily
Homologous_superfamily	IPR043145	Zinc finger, ZZ-type superfamily

Domain Details Per Protein

Protein	Length	Bromodomain	Bromodomain, conserved site	Bromodomain-like superfamily	CBP/p300, atypical RING domain superfamily	CBP/p300-type histone acetyltransferase domain	Coactivator CBP, KIX domain	Coactivator CBP, KIX domain superfamily	CREB-binding protein/p300, atypical RING domain	Histone acetyltransferase Rtt109/CBP	Nuclear receptor coactivator, CREB-bp-like, interlocking	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily	Nuclear receptor coactivator, interlocking	TAZ domain superfamily	Zinc finger, RING/FYVE/PHD-type	Zinc finger, TAZ-type	Zinc finger, ZZ-type	Zinc finger, ZZ-type superfamily
UniProtKB:A0A8M3B7G7 InterPro	2673
UniProtKB:A0A8M3B4N4 InterPro	2672
UniProtKB:A0A8M3BE74 InterPro	2663
UniProtKB:A0A8M9PFF3 InterPro	2672
UniProtKB:A0A8M9QMW4 InterPro	2681
UniProtKB:A0A8M9PYD9 InterPro	2681
UniProtKB:A0A8M3AYE1 InterPro	2661
UniProtKB:A0A8M9PSB9 InterPro	2663
UniProtKB:A0A8M9PYE4 InterPro	2661
UniProtKB:A0A8M9PSB5 InterPro	2681
UniProtKB:A0A8M9PTF6 InterPro	1975
UniProtKB:A0A8M9Q4R2 InterPro	2673
UniProtKB:A0A8M9Q0N1 InterPro	1965
UniProtKB:A0A8M3BE71 InterPro	2682
UniProtKB:A0A8M3AYD6 InterPro	2680
UniProtKB:A0A8M9PFE9 InterPro	2682
UniProtKB:A0A8M9PAU5 InterPro	1956
UniProtKB:A0A8M9Q3W4 InterPro	1966
UniProtKB:A0A8M9Q9D0 InterPro	2680

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ep300a-201 (1) Ensembl	Ensembl		8,016 nt	Select Tool ZFIN BLAST
mRNA	ep300a-202 (1) Ensembl	Ensembl		10,239 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations