Gene

ep300a

ID

ZDB-GENE-080403-16

Name

E1A binding protein p300 a

Symbol

ep300a Nomenclature History

Previous Names

EP300b1 (1)
EP300b2 (1)
P300-A (1)
gb:dq017643
im:7158255

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Exhibits histone acetyltransferase activity. Involved in embryonic cranial skeleton morphogenesis; heart looping; and pectoral fin development. Predicted to localize to histone acetyltransferase complex. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Is expressed in blastoderm; blastomere; brain; intestinal bulb; and liver. Orthologous to human EP300 (E1A binding protein p300).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7158255 (1 image)
dq017643 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ep300a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
colorectal cancer	Alliance	Colorectal cancer, somatic	114500
Rubinstein-Taybi syndrome	Alliance	Rubinstein-Taybi syndrome 2	613684
		Menke-Hennekam syndrome 2	618333

Associated With ep300a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018359	Bromodomain, conserved site
Domain	IPR000197	Zinc finger, TAZ-type
Domain	IPR000433	Zinc finger, ZZ-type
Domain	IPR001487	Bromodomain
Domain	IPR003101	Coactivator CBP, KIX domain
Domain	IPR010303	CREB-binding protein/p300, atypical RING domain
Domain	IPR014744	Nuclear receptor coactivator, CREB-bp-like, interlocking
Domain	IPR031162	CBP/p300-type histone acetyltransferase domain
Family	IPR013178	Histone acetyltransferase Rtt109/CBP
Homologous_superfamily	IPR009110	Nuclear receptor coactivator, interlocking
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR035898	TAZ domain superfamily
Homologous_superfamily	IPR036427	Bromodomain-like superfamily
Homologous_superfamily	IPR036529	Coactivator CBP, KIX domain superfamily
Homologous_superfamily	IPR037073	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily
Homologous_superfamily	IPR038547	CBP/p300, atypical RING domain superfamily
Homologous_superfamily	IPR043145	Zinc finger, ZZ-type superfamily

Domain Details Per Protein

Protein	Length	Bromodomain	Bromodomain, conserved site	Bromodomain-like superfamily	CBP/p300, atypical RING domain superfamily	CBP/p300-type histone acetyltransferase domain	Coactivator CBP, KIX domain	Coactivator CBP, KIX domain superfamily	CREB-binding protein/p300, atypical RING domain	Histone acetyltransferase Rtt109/CBP	Nuclear receptor coactivator, CREB-bp-like, interlocking	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily	Nuclear receptor coactivator, interlocking	TAZ domain superfamily	Zinc finger, RING/FYVE/PHD-type	Zinc finger, TAZ-type	Zinc finger, ZZ-type	Zinc finger, ZZ-type superfamily
UniProtKB:A0A8M3B7G7 InterPro	2673
UniProtKB:A0A8M3B4N4 InterPro	2672
UniProtKB:A0A8M3BE74 InterPro	2663
UniProtKB:A0A8M9PFF3 InterPro	2672
UniProtKB:A0A8M9QMW4 InterPro	2681
UniProtKB:A0A8M9PYD9 InterPro	2681
UniProtKB:A0A8M3AYE1 InterPro	2661
UniProtKB:A0A8M9PSB9 InterPro	2663
UniProtKB:A0A8M9PYE4 InterPro	2661
UniProtKB:A0A8M9PSB5 InterPro	2681
UniProtKB:A0A8M9PTF6 InterPro	1975
UniProtKB:A0A8M9Q4R2 InterPro	2673
UniProtKB:A0A8M9Q0N1 InterPro	1965
UniProtKB:A0A8M3BE71 InterPro	2682
UniProtKB:A0A8M3AYD6 InterPro	2680
UniProtKB:A0A8M9PFE9 InterPro	2682
UniProtKB:A0A8M9PAU5 InterPro	1956
UniProtKB:A0A8M9Q3W4 InterPro	1966
UniProtKB:A0A8M9Q9D0 InterPro	2680

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ep300a-201 (1) Ensembl	Ensembl		8,016 nt	Select Tool ZFIN BLAST
mRNA	ep300a-202 (1) Ensembl	Ensembl		10,239 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations