Gene
ncoa6
- ID
- ZDB-GENE-080403-12
- Name
- nuclear receptor coactivator 6
- Symbol
- ncoa6 Nomenclature History
- Previous Names
-
- gb:dq017635
- wu:fb25d11
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of histone methyltransferase complex and transcription regulator complex. Is expressed in embryonic structure. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017635 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nuclear receptor coactivator 6 | Nuclear receptor coactivator 6, TRADD-N domain |
|---|---|---|---|
|
UniProtKB:A0A8M2BHW9
|
2257 | ||
|
UniProtKB:F1R869
|
2271 | ||
|
UniProtKB:A0A8M1QK83
|
2269 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-186H16 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-369F3 | ZFIN Curated Data | |
| Encodes | EST | dq017635 | Bertrand et al., 2007 | |
| Encodes | EST | fb25d11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005170565 (1) | 7370 nt | ||
| Genomic | GenBank:CU861507 (2) | 21958 nt | ||
| Polypeptide | UniProtKB:F1R869 (1) | 2271 aa |
- Yang, Y., Wang, L., Han, X., Yang, W.L., Zhang, M., Ma, H.L., Sun, B.F., Li, A., Xia, J., Chen, J., Heng, J., Wu, B., Chen, Y.S., Xu, J.W., Yang, X., Yao, H., Sun, J., Lyu, C., Wang, H.L., Huang, Y., Sun, Y.P., Zhao, Y.L., Meng, A., Ma, J., Liu, F., Yang, Y.G. (2019) RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Molecular Cell. 75(6):1188-1202.e11
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ren, L., Tan, X.J., Xiong, Y.F., Xu, K., Zhou, Y., Zhong, H., Liu, Y., Hong, Y., Liu, S.J. (2014) Transcriptome analysis reveals positive selection on the divergent between topmouth culter and zebrafish. Gene. 552(2):265-71
- Bertrand, S., Thisse, B., Tavares, R., Sachs, L., Chaumot, A., Bardet, P.L., Escrivà, H., Duffraisse, M., Marchand, O., Safi, R., Thisse, C., and Laudet, V. (2007) Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression. PLoS Genetics. 3(11):e188
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