Gene

nr0b2a

ID

ZDB-GENE-080403-1

Name

nuclear receptor subfamily 0, group B, member 2a

Symbol

nr0b2a Nomenclature History

Previous Names

NR0B2-A (1)
nr0b2a (1)
gb:bc058069
SHP-A (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable transcription corepressor activity. Predicted to be involved in circadian rhythm; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Is expressed in heart and yolk syncytial layer. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR0B2 (nuclear receptor subfamily 0 group B member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

bc058069 (3 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nr0b2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
obesity	Alliance	Obesity, mild, early-onset	601665

Associated With nr0b2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000536	Nuclear hormone receptor, ligand-binding domain
Family	IPR001723	Nuclear hormone receptor
Family	IPR033544	Nuclear receptor subfamily 0 group B member 1/2
Homologous_superfamily	IPR035500	Nuclear hormone receptor-like domain superfamily