Gene
rnf207b
- ID
- ZDB-GENE-080227-9
- Name
- ring finger protein 207b
- Symbol
- rnf207b Nomenclature History
- Previous Names
-
- rnf207
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable Hsp70 protein binding activity; chaperone binding activity; and transmembrane transporter binding activity. Involved in positive regulation of voltage-gated potassium channel activity; regulation of heart contraction; and regulation of heart looping. Predicted to be located in cytoplasm. Predicted to be active in perinuclear region of cytoplasm. Orthologous to human RNF207 (ring finger protein 207).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Roder et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028500Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9730 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17871 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43968 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | B-box-type zinc finger | RING finger protein 207 | Zinc finger, C3HC4 RING-type | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B971
|
573 | ||||||
|
UniProtKB:E9QHE3
|
634 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rnf207b-202
(1)
|
Ensembl | 1,958 nt | ||
| ncRNA |
rnf207b-001
(1)
|
Ensembl | 2,506 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001201449 (1) | 2592 nt | ||
| Genomic | GenBank:CR847529 (1) | 158776 nt | ||
| Polypeptide | UniProtKB:E9QHE3 (1) | 634 aa |
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Roder, K., Werdich, A.A., Li, W., Liu, M., Kim, T.Y., Organ-Darling, L.E., Moshal, K.S., Hwang, J.M., Lu, Y., Choi, B.R., MacRae, C.A., Koren, G. (2014) RING Finger Protein RNF207, a Novel Regulator of Cardiac Excitation. The Journal of biological chemistry. 289(49):33730-40
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Boudinot, P., van der Aa, L.M., Jouneau, L., Du Pasquier, L., Pontarotti, P., Briolat, V., Benmansour, A., and Levraud, J.P. (2011) Origin and Evolution of TRIM Proteins: New Insights from the Complete TRIM Repertoire of Zebrafish and Pufferfish. PLoS One. 6(7):e22022
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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