Gene

nova2

ID

ZDB-GENE-080211-1

Name

NOVA alternative splicing regulator 2

Symbol

nova2 Nomenclature History

Previous Names

id:ibd1128
sb:cb364

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Is expressed in nervous system; neural plate; and posterior cardinal vein. Orthologous to human NOVA2 (NOVA alternative splicing regulator 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb364 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Baek et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nova2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with or without autistic features and/or structural brain abnormalities	618859

Associated With nova2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004087	K Homology domain
Domain	IPR004088	K Homology domain, type 1
Domain	IPR047274	RNA-binding protein Nova-1/2, type I K Homology domain 3
Domain	IPR047275	RNA-binding protein Nova-1/2, type I K Homology domain 1
Domain	IPR047276	RNA-binding protein Nova-1/2, type I K Homology domain 2
Homologous_superfamily	IPR036612	K Homology domain, type 1 superfamily

Domain Details Per Protein

Protein	Length	K Homology domain	K Homology domain, type 1	K Homology domain, type 1 superfamily	RNA-binding protein Nova-1/2, type I K Homology domain 1	RNA-binding protein Nova-1/2, type I K Homology domain 2	RNA-binding protein Nova-1/2, type I K Homology domain 3
UniProtKB:F1R4G7 InterPro	496
UniProtKB:X1WBB9 InterPro	517

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nova2-201 (1) Ensembl	Ensembl	1,951 nt	Select Tool
mRNA	nova2-203 (1) Ensembl	Ensembl	8,894 nt	Select Tool
mRNA	nova2-204 (1) Ensembl	Ensembl	2,372 nt	Select Tool ZFIN BLAST
mRNA	nova2-205 (1) Ensembl	Ensembl	2,309 nt	Select Tool ZFIN BLAST
ncRNA	nova2-003 (1) Ensembl	Ensembl	356 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations