Gene
myrf
- ID
- ZDB-GENE-080204-57
- Name
- myelin regulatory factor
- Symbol
- myrf Nomenclature History
- Previous Names
-
- c11orf9 (1)
- zgc:172183
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in central nervous system myelin maintenance; positive regulation of DNA-templated transcription; and protein autoprocessing. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane and nucleus. Is expressed in oligodendrocyte. Used to study eye disease. Orthologous to human MYRF (myelin regulatory factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-myrf | (2) | |
| MO1-myrf | N/A | Xiao et al., 2019 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| eye disease | AB + MO1-myrf | standard conditions | Xiao et al., 2019 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR024061 | NDT80 DNA-binding domain |
| Domain | IPR025719 | Myelin gene regulatory factor C-terminal domain 2 |
| Domain | IPR026932 | Myelin gene regulatory factor, ICA domain |
| Domain | IPR030392 | Intramolecular chaperone auto-processing domain |
| Family | IPR051577 | Myelin Regulatory Factor-like |
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Domain Details Per Protein
| Protein | Length | Intramolecular chaperone auto-processing domain | Myelin gene regulatory factor C-terminal domain 2 | Myelin gene regulatory factor, ICA domain | Myelin Regulatory Factor-like | NDT80 DNA-binding domain | NDT80 DNA-binding domain superfamily | p53-like transcription factor, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3ANV6
|
1027 | |||||||
|
UniProtKB:A0A8M9P6L9
|
1009 | |||||||
|
UniProtKB:A0A8M9PV81
|
1034 | |||||||
|
UniProtKB:A0A8M9PYN2
|
1036 | |||||||
|
UniProtKB:A0A8M3AWA7
|
1037 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(myrf:GAL4-VP16,myl7:EGFP) |
|
| 1 | Treichel et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-70E5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-247I17 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-89B12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:172183 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001201392 (1) | 2073 nt | ||
| Genomic | GenBank:CU855758 (2) | 112125 nt | ||
| Polypeptide | UniProtKB:A0A8M3AWA7 (1) | 1037 aa |
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Benardais, K., Ornelas, I.M., Fauveau, M., Brown, T.L., Finseth, L.T., Panic, R., Deboux, C., Macklin, W.B., Wood, T.L., Nait-Oumesmar, B. (2022) p70S6 kinase regulates oligodendrocyte differentiation and is active in remyelinating lesions. Brain communications. 4:fcac025
- Almeida, R.G., Williamson, J.M., Madden, M.E., Early, J.J., Voas, M.G., Talbot, W.S., Bianco, I.H., Lyons, D.A. (2021) Myelination induces axonal hotspots of synaptic vesicle fusion that promote sheath growth. Current biology : CB. 31(17):3743-3754.e5
- Kearns, C.A., Walker, M., Ravanelli, A.M., Scott, K., Arzbecker, M.R., Appel, B. (2021) Zebrafish spinal cord oligodendrocyte formation requires boc function. Genetics. 218(4):
- Madden, M.E., Suminaite, D., Ortiz, E., Early, J.E., Koudelka, S., Livesey, M.R., Bianco, I.H., Granato, M., Lyons, D.A. (2021) Central nervous system hypomyelination disrupts axonal conduction and behaviour in larval zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(44):9099-9111
- Scott, K., O'Rourke, R., Winkler, C.C., Kearns, C.A., Appel, B. (2021) Temporal single-cell transcriptomes of zebrafish spinal cord pMN progenitors reveal distinct neuronal and glial progenitor populations. Developmental Biology. 479:37-50
- Hughes, A.N., Appel, B. (2020) Microglia phagocytose myelin sheaths to modify developmental myelination. Nature Neuroscience. 23(9):1055-1066
- Marisca, R., Hoche, T., Agirre, E., Hoodless, L.J., Barkey, W., Auer, F., Castelo-Branco, G., Czopka, T. (2020) Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation. Nature Neuroscience. 23(3):363-374
- Scott, K., O'Rourke, R., Gillen, A., Appel, B. (2020) Prdm8 regulates pMN progenitor specification for motor neuron and oligodendrocyte fates by modulating Shh signaling response. Development (Cambridge, England). 147(16):
- Klingseisen, A., Ristoiu, A.M., Kegel, L., Sherman, D.L., Rubio-Brotons, M., Almeida, R.G., Koudelka, S., Benito-Kwiecinski, S.K., Poole, R.J., Brophy, P.J., Lyons, D.A. (2019) Oligodendrocyte Neurofascin Independently Regulates Both Myelin Targeting and Sheath Growth in the CNS. Developmental Cell. 51(6):730-744.e6
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