Gene

myrf

ID

ZDB-GENE-080204-57

Name

myelin regulatory factor

Symbol

myrf Nomenclature History

Previous Names

c11orf9 (1)
zgc:172183

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated. Predicted to localize to cytoplasm and nucleus. Orthologous to human MYRF (myelin regulatory factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myrf Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cardiac-urogenital syndrome	618280
		Encephalitis/encephalopathy, mild, with reversible myelin vacuolization	618113

Associated With myrf Via Experimental Models

Human Disease	Fish	Conditions	Citations
eye disease	AB + MO1-myrf	standard conditions	Xiao et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR024061	NDT80 DNA-binding domain
Domain	IPR025719	Myelin gene regulatory factor C-terminal domain 2
Domain	IPR026932	Myelin gene regulatory factor, ICA domain
Domain	IPR030392	Intramolecular chaperone auto-processing domain
Family	IPR051577	Myelin Regulatory Factor-like
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR037141	NDT80 DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Intramolecular chaperone auto-processing domain	Myelin gene regulatory factor C-terminal domain 2	Myelin gene regulatory factor, ICA domain	Myelin Regulatory Factor-like	NDT80 DNA-binding domain	NDT80 DNA-binding domain superfamily	p53-like transcription factor, DNA-binding domain superfamily
UniProtKB:A0A8M3ANV6 InterPro	1027
UniProtKB:A0A8M9P6L9 InterPro	1009
UniProtKB:A0A8M9PV81 InterPro	1034
UniProtKB:A0A8M9PYN2 InterPro	1036
UniProtKB:A0A8M3AWA7 InterPro	1037
UniProtKB:A0A8M9PH29 InterPro	1008