Gene
dock1
- ID
- ZDB-GENE-080108-5
- Name
- dedicator of cytokinesis 1
- Symbol
- dock1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Acts upstream of or within myelination in peripheral nervous system and myoblast fusion. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human DOCK1 (dedicator of cytokinesis 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001452 | SH3 domain |
| Domain | IPR027007 | C2 DOCK-type domain |
| Domain | IPR027357 | DOCKER domain |
| Domain | IPR032376 | Dedicator of cytokinesis, N-terminal domain |
| Domain | IPR046769 | DOCKER, Lobe A |
| Domain | IPR046770 | DOCKER, Lobe B |
| Domain | IPR046773 | DOCKER, Lobe C |
| Domain | IPR047025 | Dedicator of cytokinesis protein 1/5, SH3 domain |
| Domain | IPR047026 | Dedicator of cytokinesis protein 1, C2 domain |
| Family | IPR026791 | Dedicator of cytokinesis |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR042455 | Dedicator of cytokinesis, N-terminal, subdomain 1 |
| Homologous_superfamily | IPR043161 | Dedicator of cytokinesis, C-terminal, lobe A |
| Homologous_superfamily | IPR043162 | Dedicator of cytokinesis, C-terminal, lobe C |
Domain Details Per Protein
| Protein | Length | Armadillo-type fold | C2 DOCK-type domain | C2 domain superfamily | Dedicator of cytokinesis | Dedicator of cytokinesis, C-terminal, lobe A | Dedicator of cytokinesis, C-terminal, lobe C | Dedicator of cytokinesis, N-terminal domain | Dedicator of cytokinesis, N-terminal, subdomain 1 | Dedicator of cytokinesis protein 1/5, SH3 domain | Dedicator of cytokinesis protein 1, C2 domain | DOCKER domain | DOCKER, Lobe A | DOCKER, Lobe B | DOCKER, Lobe C | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A8E1V6
|
1866 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available