Gene
ptpn21
- ID
- ZDB-GENE-080102-4
- Name
- protein tyrosine phosphatase non-receptor type 21
- Symbol
- ptpn21 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within epithelial to mesenchymal transition; heart morphogenesis; and somitogenesis. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in brain; pectoral fin; pericardial region; somite; and ventricular zone. Orthologous to human PTPN21 (protein tyrosine phosphatase non-receptor type 21).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Wyatt et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000299 | FERM domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
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Domain Details Per Protein
| Protein | Length | Band 4.1 domain | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM, C-terminal PH-like domain | FERM domain | FERM, N-terminal | FERM superfamily, second domain | PH-like domain superfamily | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Protein-tyrosine phosphatase, non-receptor type-14/21 | PTPN14/21, FERM domain C-lobe | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1Q6T9
|
1168 | ||||||||||||||||
|
UniProtKB:A0A286YBL8
|
1204 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptpn21-201
(1)
|
Ensembl | 7,797 nt | ||
| mRNA |
ptpn21-202
(1)
|
Ensembl | 3,733 nt | ||
| mRNA |
ptpn21-203
(1)
|
Ensembl | 3,625 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-147B23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-248G15 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-179E15 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005169788 (1) | 5178 nt | ||
| Genomic | GenBank:CR759892 (1) | 169875 nt | ||
| Polypeptide | UniProtKB:A0A286YBL8 (1) | 1204 aa |
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Campbell, J.S., Davidson, A.J., Todd, H., Rodrigues, F.S.L.M., Elliot, A.M., Early, J.J., Lyons, D.A., Feng, Y., Wood, W. (2020) PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo. Current biology : CB. 31(4):875-883.e5
- Wu, W., Hale, A.J., Lemeer, S., den Hertog, J. (2017) Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Scientific Reports. 7:8460
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Overman, J.P., and den Hertog, J. (2014) Zebrafish as a model to study PTPs during development. Methods (San Diego, Calif.). 65(2):247-53
- van Eekelen, M., Overvoorde, J., van Rooijen, C., and den Hertog, J. (2010) Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. PLoS One. 5(9):e12573
- Wyatt, L., Wadham, C., Crocker, L.A., Lardelli, M., and Khew-Goodall, Y. (2007) The protein tyrosine phosphatase Pez regulates TGF{beta}, epithelial mesenchymal transition, and organ development. The Journal of cell biology. 178(7):1223-1235
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