Gene
pglyrp6
- ID
- ZDB-GENE-071227-2
- Name
- peptidoglycan recognition protein 6
- Symbol
- pglyrp6 Nomenclature History
- Previous Names
-
- zfPGRP6 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables N-acetylmuramoyl-L-alanine amidase activity. Acts upstream of or within defense response to bacterium. Is expressed in several structures, including acinar cell; gill lamella; gut absorptive cell; liver; and pleuroperitoneal region. Orthologous to human PGLYRP2 (peptidoglycan recognition protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002502 | N-acetylmuramoyl-L-alanine amidase domain |
| Domain | IPR006619 | Peptidoglycan recognition protein family domain, metazoa/bacteria |
| Family | IPR015510 | Peptidoglycan recognition protein |
| Homologous_superfamily | IPR036505 | N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily |
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Domain Details Per Protein
| Protein | Length | N-acetylmuramoyl-L-alanine amidase domain | N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily | Peptidoglycan recognition protein | Peptidoglycan recognition protein family domain, metazoa/bacteria |
|---|---|---|---|---|---|
|
UniProtKB:B7ZUU1
|
497 | ||||
|
UniProtKB:A0A0R4IJX9
|
498 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pglyrp6-201
(1)
|
Ensembl | 1,611 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-108N20 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198076 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045222 (1) | 1611 nt | ||
| Genomic | GenBank:CU929085 (1) | 65427 nt | ||
| Polypeptide | UniProtKB:A0A0R4IJX9 (1) | 498 aa |
No data available
- Cao, L., Fang, H., Yan, D., Wu, X.M., Zhang, J., Chang, M.X. (2022) CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Communications biology. 5:889
- Wu, X.M., Cao, L., Nie, P., Chang, M.X. (2019) Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes. Developmental and comparative immunology. 101:103455
- Zhang, F., Shan, S., Xu, X., Wang, Y., Zhang, Y., Yin, M., Yang, G. (2019) Molecular characterization and expression analysis of two peptidoglycan recognition proteins (CcPGRP5, CcPGRP6) in larvae ontogeny of common carp Cyprinus carpio L. and upon immune stimulation by bacteria. BMC veterinary research. 15:10
- Hu, Y.W., Wu, X.M., Ren, S.S., Cao, L., Nie, P., Chang, M.X. (2017) NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway. Scientific Reports. 7:2979
- Ruyra, A., Torrealba, D., Morera, D., Tort, L., MacKenzie, S., Roher, N. (2015) Zebrafish liver (ZFL) cells are able to mount an anti-viral response after stimulation with Poly (I:C). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 182:55-63
- Li, J.H., Yu, Z.L., Xue, N.N., Zou, P.F., Hu, J.Y., Nie, P., and Chang, M.X. (2014) Molecular cloning and functional characterization of peptidoglycan recognition protein 6 in grass carp Ctenopharyngodon idella. Developmental and comparative immunology. 42(20):244-255
- Oehlers, S.H., Flores, M.V., Chen, T., Hall, C.J., Crosier, K.E., and Crosier, P.S. (2011) Topographical distribution of antimicrobial genes in the zebrafish intestine. Developmental and comparative immunology. 35(3):385-391
- Kim, M.Y., Jang, J.H., Lee, J.W., and Cho, J.H. (2010) Molecular cloning and characterization of peptidoglycan recognition proteins from the rockfish, Sebastes schlegeli. Fish & shellfish immunology. 28(4):632-369
- Chang, M.X., and Nie, P. (2008) RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare. Veterinary Immunology and Immunopathology. 124(3-4):295-301
- Chang, M.X., Nie, P., and Wei, L.L. (2007) Short and long peptidoglycan recognition proteins (PGRPs) in zebrafish, with findings of multiple PGRP homologs in teleost fish. Molecular immunology. 44(11):3005-3023
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