Gene
neu3.5
- ID
- ZDB-GENE-071220-2
- Name
- sialidase 3 (membrane sialidase), tandem duplicate 5
- Symbol
- neu3.5 Nomenclature History
- Previous Names
-
- si:dkey-11j5.6
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable exo-alpha-sialidase activity. Predicted to be involved in ganglioside catabolic process and oligosaccharide catabolic process. Predicted to act upstream of or within lipid catabolic process. Predicted to be active in lysosome and membrane. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Orthologous to human NEU3 (neuraminidase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Sialidase | Sialidase family | Sialidase superfamily |
|---|---|---|---|---|
|
UniProtKB:A0A0R4IGG5
|
398 | |||
|
UniProtKB:A7TUD6
|
398 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
neu3.5-201
(1)
|
Ensembl | 1,191 nt | ||
| mRNA |
neu3.5-202
(1)
|
Ensembl | 1,197 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-82A9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001109733 (1) | |||
| Genomic | GenBank:BX005026 (1) | 154034 nt | ||
| Polypeptide | UniProtKB:A0A0R4IGG5 (1) | 398 aa |
- Okada, K., Takase, R., Hamaoka, Y., Honda, A., Ikeda, A., Hokazono, Y., Maeda, Y., Hayasaka, O., Kotani, T., Komatsu, M., Shiozaki, K. (2020) Establishment and characterization of Neu1-knockout zebrafish and its abnormal clinical phenotypes. The Biochemical journal. 477(15):2841-2857
- Shiozaki, K., Uezono, K., Hirai, G., Honda, A., Minoda, M., Wakata, R. (2020) Identification of novel fish sialidase genes responsible for KDN-cleaving activity. Glycoconjugate journal. 37(6):745-753
- Yamakawa, N., Vanbeselaere, J., Chang, L.Y., Yu, S.Y., Ducrocq, L., Harduin-Lepers, A., Kurata, J., Aoki-Kinoshita, K.F., Sato, C., Khoo, K.H., Kitajima, K., Guerardel, Y. (2018) Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Nature communications. 9:4647
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Shiozaki, K., Takeshita, K., Ikeda, M., Ikeda, A., Harasaki, Y., Komatsu, M., Yamada, S., Yamaguchi, K., and Miyagi, T. (2013) Molecular cloning and biochemical characterization of two novel Neu3 sialidases, neu3a and neu3b, from medaka (Oryzias latipes). Biochimie. 95(2):280-289
- Manzoni, M., Colombi, P., Papini, N., Rubaga, L., Tiso, N., Preti, A., Venerando, B., Tettamanti, G., Bresciani, R., Argenton, F., Borsani, G., and Monti, E. (2007) Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio). The Biochemical journal. 408(3):395-406
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