Gene
tyk2
- ID
- ZDB-GENE-071116-4
- Name
- tyrosine kinase 2
- Symbol
- tyk2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to localize to cytoskeleton and membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TYK2 (tyrosine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Gao et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 35 | Alliance | Immunodeficiency 35 | 611521 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR016045 | Tyrosine-protein kinase, non-receptor, TYK2, N-terminal |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR041046 | JAK, FERM F2 lobe domain |
| Domain | IPR041155 | FERM F1 lobe ubiquitin-like domain |
| Domain | IPR041381 | JAK1-3/TYK2, pleckstrin homology-like domain |
| Family | IPR016251 | Tyrosine-protein kinase, non-receptor Jak/Tyk2 |
| Family | IPR051286 | Janus Kinase (JAK) |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Band 4.1 domain | FERM central domain | FERM domain | FERM F1 lobe ubiquitin-like domain | FERM superfamily, second domain | JAK1-3/TYK2, pleckstrin homology-like domain | JAK, FERM F2 lobe domain | Janus Kinase (JAK) | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, non-receptor Jak/Tyk2 | Tyrosine-protein kinase, non-receptor, TYK2, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BBI7
|
1164 | ||||||||||||||||||
|
UniProtKB:A0A8M3AQW8
|
1165 |
Interactions and Pathways
No data available
Plasmids
No data available