Gene
ripk3
- ID
- ZDB-GENE-071115-4
- Name
- receptor-interacting serine-threonine kinase 3
- Symbol
- ripk3 Nomenclature History
- Previous Names
-
- ripk3l
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hkz19 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| szy12 | Allele with one deletion | Exon 1 | Premature Stop | not specified | |
| vu701 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| vu702 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| zf3223 | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Family | IPR050167 | Serine/threonine-protein kinase |
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Domain Details Per Protein
| Protein | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase | Serine/threonine-protein kinase, active site | Serine-threonine/tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1PSS7
|
433 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-142G20 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-74B6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001343791 (1) | 2922 nt | ||
| Genomic | GenBank:BX571691 (2) | 79440 nt | ||
| Polypeptide | UniProtKB:A0A8M1PSS7 (1) | 433 aa |
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- Jim, K.K., Aprianto, R., Koning, R., Domenech, A., Kurushima, J., van de Beek, D., Vandenbroucke-Grauls, C.M.J.E., Bitter, W., Veening, J.W. (2022) Pneumolysin promotes host cell necroptosis and bacterial competence during pneumococcal meningitis as shown by whole-animal dual RNA-seq. Cell Reports. 41:111851111851
- Roca, F.J., Whitworth, L.J., Prag, H.A., Murphy, M.P., Ramakrishnan, L. (2022) Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport. Science (New York, N.Y.). 376:eabh2841
- Wen, W., Chen, J., Zhou, Y., Li, G., Zhang, Y. (2022) Loss of Ripk3 attenuated neutrophil accumulation in a lipopolysaccharide-induced zebrafish inflammatory model. Cell death discovery. 8:88
- Dai, Y., Cao, Y., Chen, Z., Huang, J., Xiao, J., Zou, J., Feng, H. (2021) RIPK3 collaborates with RIPK1 to inhibit MAVS-mediated signaling during black carp antiviral innate immunity. Fish & shellfish immunology. 115:142-149
- Yang, B., Maddison, L.A., Zaborska, K.E., Dai, C., Yin, L., Tang, Z., Zang, L., Jacobson, D.A., Powers, A.C., Chen, W. (2020) RIPK3-mediated inflammation is a conserved β cell response to ER stress. Science advances. 6(51):
- Yu, T., Kuang, H., Chen, J., Lin, X., Wu, Y., Chen, K., Zhang, M., Zhang, W., Wen, Z. (2020) Tripartite-motif family protein 35-28 regulates microglia development by preventing necrotic death of microglial precursors in zebrafish. The Journal of biological chemistry. 295(26):8846-8856
- Roca, F.J., Whitworth, L.J., Redmond, S., Jones, A.A., Ramakrishnan, L. (2019) TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit. Cell. 178(6):1344-1361.e11
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Viringipurampeer, I.A., Shan, X., Gregory-Evans, K., Zhang, J.P., Mohammadi, Z., and Gregory-Evans, C.Y. (2014) Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish. Cell death and differentiation. 21(11):1320-9
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