Gene
ikbkb
- ID
- ZDB-GENE-071115-2
- Name
- inhibitor of nuclear factor kappa B kinase subunit beta
- Symbol
- ikbkb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables kinase activity. Acts upstream of or within regulation of cytokinesis and skin development. Predicted to be located in nucleus. Predicted to be part of IkappaB kinase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; combined immunodeficiency (multiple); liver cancer; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Anelli et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Shen et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 15A | Alliance | Immunodeficiency 15A | 618204 |
| immunodeficiency 15B | Alliance | Immunodeficiency 15B | 615592 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000626 | Ubiquitin-like domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR041185 | IKBKB, scaffold dimerization domain |
| Family | IPR051180 | Inhibitor of nuclear factor kappa-B kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR046375 | IKBKB, scaffold dimerization domain superfamily |
Domain Details Per Protein
| Protein | Length | IKBKB, scaffold dimerization domain | IKBKB, scaffold dimerization domain superfamily | Inhibitor of nuclear factor kappa-B kinase | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Ubiquitin-like domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1NIE6
|
779 |
Interactions and Pathways
No data available
Plasmids
No data available