Gene
pdzrn3b
- ID
- ZDB-GENE-071022-4
- Name
- PDZ domain containing RING finger 3b
- Symbol
- pdzrn3b Nomenclature History
- Previous Names
-
- pdzrn3
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in neuromuscular junction development and protein ubiquitination. Predicted to be located in cytoplasm and synapse. Is expressed in several structures, including hindbrain neural plate; nervous system; notochord; optic vesicle; and presumptive neural retina. Orthologous to human PDZRN3 (PDZ domain containing ring finger 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015930Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la015931Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa20799 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40775 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | E3 ubiquitin-protein ligase PDZ domain-containing protein | PDZ domain | PDZ superfamily | U-box domain | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7FDW2
|
1053 | |||||||
|
UniProtKB:A0A8M2BDD2
|
772 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pdzrn3b-201
(1)
|
Ensembl | 4,320 nt | ||
| mRNA |
pdzrn3b-203
(1)
|
Ensembl | 5,753 nt | ||
| mRNA |
pdzrn3b-204
(1)
|
Ensembl | 5,723 nt | ||
| ncRNA |
pdzrn3b-002
(1)
|
Ensembl | 555 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-2E18 | ZFIN Curated Data | |
| Contained in | BAC | CH211-207E21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-237J17 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001256392 (1) | 3162 nt | ||
| Genomic | GenBank:BX119974 (2) | 213058 nt | ||
| Polypeptide | UniProtKB:E7FDW2 (1) | 1053 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Cardozo, M.J., Sánchez-Arrones, L., Sandonis, A., Sánchez-Camacho, C., Gestri, G., Wilson, S.W., Guerrero, I., Bovolenta, P. (2014) Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle. Nature communications. 5:4272
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Andreazzoli, M., Gestri, G., Landi, E., D'Orsi, B., Barilari, M., Iervolino, A., Vitiello, M., Wilson, S.W., and Dente, L. (2012) Kidins220/ARMS interacts with Pdzrn3, a protein containing multiple binding domains. Biochimie. 94(9):2054-2057
- Dente, L., Gestri, G., Tsang, M., Kudoh, T., Wilson, S.W., Dawid, I.B., and Andreazzoli, M. (2011) Cloning and developmental expression of zebrafish pdzrn3. The International journal of developmental biology. 55(10-12):989-993
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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