Gene
egf
- ID
- ZDB-GENE-070922-1
- Name
- epidermal growth factor
- Symbol
- egf Nomenclature History
- Previous Names
-
- sb:eu639
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity and growth factor activity. Acts upstream of or within blood circulation and cartilage development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; notochord; opercular flap; pleuroperitoneal region; and scale. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu639 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Pruvot et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| renal hypomagnesemia 4 | Alliance | ?Hypomagnesemia 4, renal | 611718 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR024731 | EGF domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR016317 | Pro-epidermal growth factor |
| Family | IPR050778 | Cueball/EGF/LRP/Nidogen |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR000033 | LDLR class B repeat |
Domain Details Per Protein
| Protein | Length | Cueball/EGF/LRP/Nidogen | EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | LDLR class B repeat | NOTCH1 EGF-like calcium-binding domain | Pro-epidermal growth factor | Six-bladed beta-propeller, TolB-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6VQA2
|
1114 | |||||||||||
|
UniProtKB:A0A8M9QAZ6
|
1138 | |||||||||||
|
UniProtKB:A0A8M9PZ53
|
1176 |
Interactions and Pathways
Plasmids
No data available