Gene
nfatc4
- ID
- ZDB-GENE-070912-659
- Name
- nuclear factor of activated T cells 4
- Symbol
- nfatc4 Nomenclature History
- Previous Names
-
- si:dkeyp-66d1.4 (1)
- si:dkeyp-66d1.5
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in calcineurin-NFAT signaling cascade and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human NFATC4 (nuclear factor of activated T cells 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Pistocchi et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9818 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32970 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32971 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32972 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39889 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002909 | IPT domain |
| Domain | IPR011539 | Rel homology domain, DNA-binding domain |
| Domain | IPR032397 | Rel homology dimerisation domain |
| Family | IPR008366 | Nuclear factor of activated T cells (NFAT) |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Nuclear factor of activated T cells (NFAT) | p53-like transcription factor, DNA-binding domain superfamily | Rel homology dimerisation domain | Rel homology domain, DNA-binding domain | Rel homology domain (RHD), DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F059
|
865 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nfatc4-201
(1)
|
Ensembl | 3,769 nt | ||
| mRNA |
nfatc4-202
(1)
|
Ensembl | 944 nt | ||
| ncRNA |
nfatc4-003
(1)
|
Ensembl | 861 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-66D1 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_685091 (1) | 2998 nt | ||
| Genomic | GenBank:BX511153 (2) | 129564 nt | ||
| Polypeptide | UniProtKB:E7F059 (1) | 865 aa |
- Chu, L., Terasaki, M., Mattsson, C.L., Teinturier, R., Charbord, J., Dirice, E., Liu, K.C., Miskelly, M.G., Zhou, Q., Wierup, N., Kulkarni, R.N., Andersson, O. (2022) In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system. Cell chemical biology. 29(9):1368-1380.e5
- Lin, S.J., Chiang, M.C., Shih, H.Y., Hsu, L.S., Yeh, T.H., Huang, Y.C., Lin, C.Y., Cheng, Y.C. (2017) Regulator of G protein signaling 2 (Rgs2) regulates neural crest development through Pparδ-Sox10 cascade. Biochimica et biophysica acta. 1864(3):463-474
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Pistocchi, A., Gaudenzi, G., Foglia, E., Monteverde, S., Moreno-Fortuny, A., Pianca, A., Cossu, G., Cotelli, F., and Messina, G. (2013) Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution. Development (Cambridge, England). 140(7):1528-1536
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