Gene

gad1a

ID

ZDB-GENE-070912-472

Name

glutamate decarboxylase 1a

Symbol

gad1a Nomenclature History

Previous Names

si:dkey-249g23.3

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable glutamate decarboxylase activity. Predicted to be involved in gamma-aminobutyric acid biosynthetic process. Predicted to act upstream of or within carboxylic acid metabolic process. Predicted to be active in cytoplasm and presynaptic active zone. Is expressed in brain. Human ortholog(s) of this gene implicated in anxiety disorder; bipolar disorder; developmental and epileptic encephalopathy 89; and schizophrenia. Orthologous to human GAD1 (glutamate decarboxylase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gad1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 89	Alliance	Developmental and epileptic encephalopathy 89	619124

Associated With gad1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR021115	Pyridoxal-phosphate binding site
Family	IPR002129	Pyridoxal phosphate-dependent decarboxylase
Homologous_superfamily	IPR015421	Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily	IPR015424	Pyridoxal phosphate-dependent transferase

Domain Details Per Protein

Protein	Length	Pyridoxal-phosphate binding site	Pyridoxal phosphate-dependent decarboxylase	Pyridoxal phosphate-dependent transferase	Pyridoxal phosphate-dependent transferase, major domain
UniProtKB:A0A8M9QB27 InterPro	571
UniProtKB:A0A8M9QJY1 InterPro	548
UniProtKB:A0A8M1RDR2 InterPro	591

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	gad1a-201 (1) Ensembl	Ensembl		1,788 nt	Select Tool ZFIN BLAST
mRNA	gad1a-202 (1) Ensembl	Ensembl		1,776 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations