Gene
irf4a
- ID
- ZDB-GENE-070912-330
- Name
- interferon regulatory factor 4a
- Symbol
- irf4a Nomenclature History
- Previous Names
-
- irf4
- si:ch73-170d1.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within lymphoid lineage cell migration into thymus; lymphoid progenitor cell differentiation; and negative regulation of myeloid cell differentiation. Located in chromatin and nucleus. Is expressed in several structures, including hematopoietic multipotent progenitor cell; hematopoietic system; liver; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; anaplastic large cell lymphoma; chronic lymphocytic leukemia; multiple myeloma; and peripheral T-cell lymphoma. Orthologous to human IRF4 (interferon regulatory factor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Skin/hair/eye pigmentation, variation in, 8] | 611724 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019817 | Interferon regulatory factor, conserved site |
| Domain | IPR001346 | Interferon regulatory factor, DNA-binding domain |
| Domain | IPR019471 | Interferon regulatory factor-3 |
| Homologous_superfamily | IPR008984 | SMAD/FHA domain superfamily |
| Homologous_superfamily | IPR017855 | SMAD-like domain superfamily |
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Domain Details Per Protein
| Protein | Length | Interferon regulatory factor-3 | Interferon regulatory factor, conserved site | Interferon regulatory factor, DNA-binding domain | SMAD/FHA domain superfamily | SMAD-like domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1NI50
|
460 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-170D1 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001122710 (1) | 1633 nt | ||
| Genomic | GenBank:CT962510 (1) | 85653 nt | ||
| Polypeptide | UniProtKB:A0A8M1NI50 (1) | 460 aa |
- Zhu, Y., Yang, G. (2022) Molecular identification and functional characterization of IRF4 from common carp (Cyprinus carpio. L) in immune response: a negative regulator in the IFN and NF-κB signalling pathways. BMC veterinary research. 18:106
- Chrystal, P.W., French, C.R., Jean, F., Havrylov, S., van Baarle, S., Peturson, A.M., Xu, P., Crump, J.G., Pilgrim, D.B., Lehmann, O.J., Waskiewicz, A.J. (2021) The Axenfeld-Rieger Syndrome Gene FOXC1 Contributes to Left-Right Patterning. Genes. 12(2):
- Gou, Y., Sun, W., Liu, L., Zhang, M., Du, J., Wang, R., Xu, X. (2020) Construction of irf4a Transgenic Zebrafish Using Tol2 System and Its Potential Application. Dose-response : a publication of International Hormesis Society. 18:1559325820926733
- Lu, X., Zhang, Y., Liu, F., Wang, L. (2020) Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus during Zebrafish Embryogenesis. Journal of immunology (Baltimore, Md. : 1950). 204(9):2447-2454
- Wei, Z., Li, C., Zhang, Y., Lin, C., Zhang, Y., Shu, L., Luo, L., Zhuo, J., Li, L. (2020) Macrophage-Derived IL-1β Regulates Emergency Myelopoiesis via the NF-κB and C/ebpβ in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 205(10):2694-2706
- Huang, Y., Lu, Y., He, Y., Feng, Z., Zhan, Y., Huang, X., Liu, Q., Zhang, J., Li, H., Huang, H., Ma, M., Luo, L., Li, L. (2019) Ikzf1 regulates embryonic T lymphopoiesis via Ccr9 & Irf4 in zebrafish. The Journal of biological chemistry. 294(44):16152-16163
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Liu, Z.Z., Wang, Z.L., Choi, T.I., Huang, W.T., Wang, H.T., Han, Y.Y., Zhu, L.Y., Kim, H.T., Choi, J.H., Lee, J.S., Kim, H.G., Zhao, J., Chen, Y., Lu, Z., Tian, X.L., Pan, B.X., Li, B.M., Kim, C.H., Xu, H. (2018) Chd7 Is Critical for Early T-Cell Development and Thymus Organogenesis in Zebrafish. The American journal of pathology. 188(4):1043-1058
- Mahony, C.B., Pasche, C., Bertrand, J.Y. (2018) Oncostatin M and Kit-Ligand Control Hematopoietic Stem Cell Fate during Zebrafish Embryogenesis. Stem Cell Reports. 10(6):1920-1934
- Xiong, G., Zou, L., Deng, Y., Meng, Y., Liao, X., Lu, H. (2018) Clethodim exposure induces developmental immunotoxicity and neurobehavioral dysfunction in zebrafish embryos. Fish & shellfish immunology. 86:549-558
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