Gene
dnah7
- ID
- ZDB-GENE-070912-282
- Name
- dynein, axonemal, heavy chain 7
- Symbol
- dnah7 Nomenclature History
- Previous Names
-
- si:ch211-284h20.3
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity; calcium ion binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within determination of liver left/right asymmetry. Predicted to be located in cilium; cytoplasm; and microtubule. Predicted to be part of dynein complex. Is expressed in Kupffer's vesicle. Orthologous to human DNAH7 (dynein axonemal heavy chain 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sampaio et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sampaio et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1268 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa1875 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa2518 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa7185 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa8404 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa8862 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa10194 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11115 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21492 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27405 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ciliary dyskinesia, primary, 50 | 620356 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | Dynein heavy chain | Dynein heavy chain 3, AAA+ lid domain | Dynein heavy chain, AAA1 domain, small subdomain | Dynein heavy chain, AAA 5 extension domain | Dynein heavy chain AAA lid domain | Dynein heavy chain AAA lid domain superfamily | Dynein heavy chain, AAA module D4 | Dynein heavy chain, ATP-binding dynein motor region | Dynein heavy chain, coiled coil stalk | Dynein heavy chain, C-terminal domain | Dynein heavy chain, C-terminal domain, barrel region | Dynein heavy chain, domain 2, N-terminal | Dynein heavy chain, hydrolytic ATP-binding dynein motor region | Dynein heavy chain, linker | Dynein heavy chain, linker, subdomain 3 | Dynein heavy chain region D6 P-loop domain | EF-Hand 1, calcium-binding site | EF-hand domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7UQZ5
|
4005 | ||||||||||||||||||||
|
UniProtKB:A0A8M3AW24
|
3927 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-260B17 | ZFIN Curated Data | |
| Contained in | BAC | CH211-284H20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-187E3 | ZFIN Curated Data | |
| Encodes | EST | wz12356 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_685051 (1) | 15193 nt | ||
| Genomic | GenBank:BX323457 (1) | 172918 nt | ||
| Polypeptide | UniProtKB:A0A8N7UQZ5 (1) | 4005 aa |
- Jacinto, R., Sampaio, P., Roxo-Rosa, M., Pestana, S., Lopes, S.S. (2021) Pkd2 Affects Cilia Length and Impacts LR Flow Dynamics and Dand5. Frontiers in cell and developmental biology. 9:624531
- Keatinge, M., Tsarouchas, T.M., Munir, T., Porter, N.J., Larraz, J., Gianni, D., Tsai, H.H., Becker, C.G., Lyons, D.A., Becker, T. (2021) CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genetics. 17:e1009515
- Wang, Y., Troutwine, B.R., Zhang, H., Gray, R.S. (2021) The axonemal dynein heavy chain 10 gene is essential for monocilia motility and spine alignment in zebrafish. Developmental Biology. 482:82-90
- Zhang, Y., Wang, Y., Yao, X., Wang, C., Chen, F., Liu, D., Shao, M., Xu, Z. (2020) Rbm24a Is Necessary for Hair Cell Development Through Regulating mRNA Stability in Zebrafish. Frontiers in cell and developmental biology. 8:604026
- Tavares, B., Jacinto, R., Sampaio, P., Pestana, S., Pinto, A., Vaz, A., Roxo-Rosa, M., Gardner, R., Lopes, T., Schilling, B., Henry, I., Saúde, L., Lopes, S.S. (2017) Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer.. eLIFE. 6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Martins, R., Vieira, F.A., Power, D.M. (2014) Calcitonin receptor family evolution and fishing for function using in silico promoter analysis. General and comparative endocrinology. 209:61-73
- Sampaio, P., Ferreira, R.R., Guerrero, A., Pintado, P., Tavares, B., Amaro, J., Smith, A.A., Montenegro-Johnson, T., Smith, D.J., Lopes, S.S. (2014) Left-Right Organizer Flow Dynamics: How Much Cilia Activity Reliably Yields Laterality?. Developmental Cell. 29(6):716-28
- Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nature Genetics. 23(1):86-89
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