Gene

si:ch211-195h23.3

ID

ZDB-GENE-070912-174

Name

si:ch211-195h23.3

Symbol

si:ch211-195h23.3 Nomenclature History

Previous Names

CARD-rel (1)
Gene2604 (1)
Gene38616 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Involved in negative regulation of NF-kappaB transcription factor activity. Localizes to nucleus. Is expressed in kidney and spleen. Orthologous to human CARD8 (caspase recruitment domain family member 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Chang et al., 2010

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With si:ch211-195h23.3 Human Ortholog

No data available

Associated With si:ch211-195h23.3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001315	CARD domain
Domain	IPR003191	Guanylate-binding protein/Atlastin, C-terminal
Domain	IPR015894	Guanylate-binding protein, N-terminal
Domain	IPR025307	FIIND domain
Domain	IPR030386	GB1/RHD3-type guanine nucleotide-binding (G) domain
Domain	IPR033516	CARD8/ASC/NALP1, CARD domain
Domain	IPR037684	Guanylate-binding protein, C-terminal
Family	IPR051249	NLRP Inflammasome
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036543	Guanylate-binding protein, C-terminal domain superfamily

Domain Details Per Protein

Protein	Length	CARD8/ASC/NALP1, CARD domain	CARD domain	Death-like domain superfamily	FIIND domain	GB1/RHD3-type guanine nucleotide-binding (G) domain	Guanylate-binding protein/Atlastin, C-terminal	Guanylate-binding protein, C-terminal	Guanylate-binding protein, C-terminal domain superfamily	Guanylate-binding protein, N-terminal	NLRP Inflammasome	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M9QAJ2 InterPro	658
UniProtKB:A0A8M9QJG0 InterPro	469
UniProtKB:A0A8M9QF56 InterPro	917
UniProtKB:A0A8M9QAI5 InterPro	998
UniProtKB:A0A8M9PRT1 InterPro	730
UniProtKB:A0A8M9PRS7 InterPro	996
UniProtKB:B0V1H3 InterPro	478
UniProtKB:A0A8M9Q4E9 InterPro	1001
UniProtKB:A0A8M9QAI8 InterPro	970