Gene
tagln
- ID
- ZDB-GENE-070912-1
- Name
- transgelin
- Symbol
- tagln Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to be active in cytoskeleton. Is expressed in several structures, including artery; gut; hematopoietic stem cell; smooth muscle; and swim bladder bud. Orthologous to human TAGLN (transgelin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calponin homology domain | Calponin-like | Calponin repeat | CH domain superfamily | Smooth muscle protein/calponin |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QHD6
|
206 | |||||
|
UniProtKB:Q0P4B4
|
199 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(tagln:cald1l-GFP) |
|
| 1 | (3) | |
| Tg2(tagln:cald1l-GFP) |
|
| 1 | (3) | |
| TgBAC(tagln:EGFP) |
|
| 1 | (5) | |
| Tg(tagln:CAAX-EGFP) |
|
| 1 | (3) | |
| Tg(tagln:ECR-GAL4) |
|
| 1 | Stratman et al., 2017 | |
| Tg(tagln:GFP) |
|
| 1 | (12) | |
| Tg(tagln:mCherry) |
|
| 1 | Elworthy et al., 2019 | |
| Tg(tagln:NLS-EGFP-2A-CFP-FTASE) |
|
| 1 | Stratman et al., 2017 | |
| Tg(tagln:NLS-mCherry) |
|
| 1 | Chhabria et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-144D13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153186 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045467 (1) | 823 nt | ||
| Genomic | GenBank:CU469509 (2) | 105182 nt | ||
| Polypeptide | UniProtKB:A0A8M9QHD6 (1) | 206 aa |
- Zhang, J., Liang, Y., Zeng, W., Gao, X., Wang, D., Mai, C., Lin, Z., Zhao, H., Li, X. (2024) Inducing aortic aneurysm/dissection in zebrafish: evaluating the efficacy of β-Aminopropionic Nitrile as a model. Animal cells and systems. 28:849284-92
- Gao, Y., Jin, Q., Gao, C., Chen, Y., Sun, Z., Guo, G., Peng, J. (2022) Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver. Cells. 11(20):
- Kapuria, S., Bai, H., Fierros, J., Huang, Y., Ma, F., Yoshida, T., Aguayo, A., Kok, F., Wiens, K.M., Yip, J.K., McCain, M.L., Pellegrini, M., Nagashima, M., Hitchcock, P.F., Mochizuki, N., Lawson, N.D., Harrison, M.M.R., Lien, C.L. (2022) Heterogeneous pdgfrβ+ cells regulate coronary vessel development and revascularization during heart regeneration. Development (Cambridge, England). 149(4):
- Leonard, E.V., Figueroa, R.J., Bussmann, J., Lawson, N.D., Amigo, J.D., Siekmann, A.F. (2022) Regenerating vascular mural cells in zebrafish fin blood vessels are not derived from pre-existing ones and differentially require pdgfrb signalling for their development. Development (Cambridge, England). 149(7)
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Zada, A., Zhao, Y., Halim, D., Windster, J., van der Linde, H.C., Glodener, J., Overkleeft, S., de Graaf, B.M., Verdijk, R.M., Brooks, A.S., Shepherd, I., Gao, Y., Burns, A.J., Hofstra, R.M.W., Alves, M.M. (2022) The long Filamin-a isoform is required for intestinal development and motility: implications for chronic intestinal pseudo-obstruction. Human molecular genetics. 32(1):151-160
- Fowler, G., French, D., Rose, A., Squires, P., Anecito da Silva, C., Ohata, S., Okamoto, H., French, C.R. (2021) Protein fucosylation is required for Notch dependent vascular integrity in zebrafish. Developmental Biology. 480:62-68
- Ogawa, M., Geng, F.S., Humphreys, D.T., Kristianto, E., Sheng, D.Z., Hui, S.P., Zhang, Y., Sugimoto, K., Nakayama, M., Zheng, D., Hesselson, D., Hodson, M.P., Bogdanovic, O., Kikuchi, K. (2021) Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish. Science (New York, N.Y.). 372:201-205
- Hou, Y., Lee, H.J., Chen, Y., Ge, J., Osman, F.O.I., McAdow, A.R., Mokalled, M.H., Johnson, S.L., Zhao, G., Wang, T. (2020) Cellular diversity of the regenerating caudal fin. Science advances. 6:eaba2084
- Chhabria, K., Vouros, A., Gray, C., MacDonald, R.B., Jiang, Z., Wilkinson, R.N., Plant, K., Vasilaki, E., Howarth, C., Chico, T.J.A. (2019) Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish. Disease models & mechanisms. 12(9):
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