Gene
adamts18
- ID
- ZDB-GENE-070815-1
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 18
- Symbol
- adamts18 Nomenclature History
- Previous Names
-
- sb:eu2468
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Acts upstream of or within angiogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including anterior axial hypoblast; digestive system; nervous system; neural keel; and pleuroperitoneal region. Orthologous to human ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif 18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2468 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Lu et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Microcornea, myopic chorioretinal atrophy, and telecanthus | 615458 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
| Domain | IPR002870 | Peptidase M12B, propeptide |
| Domain | IPR010294 | ADAMTS/ADAMTS-like, Spacer 1 |
| Domain | IPR010909 | PLAC |
| Domain | IPR041645 | ADAMTS, cysteine-rich domain 2 |
| Domain | IPR045371 | ADAMTS/ADAMTS-like, cysteine-rich domain 3 |
| Family | IPR013273 | ADAMTS/ADAMTS-like |
| Family | IPR050439 | ADAMTS and ADAMTS-like |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
| Protein | Length | ADAMTS/ADAMTS-like | ADAMTS/ADAMTS-like, cysteine-rich domain 3 | ADAMTS/ADAMTS-like, Spacer 1 | ADAMTS and ADAMTS-like | ADAMTS, cysteine-rich domain 2 | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | PLAC | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PQ18
|
1014 | |||||||||||
|
UniProtKB:E7FEJ5
|
1244 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adamts18-201
(1)
|
Ensembl | 7,365 nt | ||
| mRNA |
adamts18-202
(1)
|
Ensembl | 696 nt |
Interactions and Pathways
No data available
Plasmids
No data available