Gene
adamts13
- ID
- ZDB-GENE-070814-7
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 13
- Symbol
- adamts13 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables peptidase activity. Involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in blood plasma. Human ortholog(s) of this gene implicated in thrombotic thrombocytopenic purpura. Orthologous to human ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif 13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zheng et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Zheng et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thrombotic thrombocytopenic purpura | Alliance | Thrombotic thrombocytopenic purpura, hereditary | 274150 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ADAMTS/ADAMTS-like | ADAMTS/ADAMTS-like, cysteine-rich domain 3 | ADAMTS/ADAMTS-like, Spacer 1 | ADAMTS and ADAMTS-like | ADAMTS, cysteine-rich domain 2 | CUB domain | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Spermadhesin, CUB domain superfamily | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PZM1
|
1498 | |||||||||||
|
UniProtKB:A0A286Y999
|
1498 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adamts13-201
(1)
|
Ensembl | 4,345 nt | ||
| mRNA |
adamts13-202
(1)
|
Ensembl | 5,260 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-220M6 | ||
| Contained in | BAC | DKEY-281F2 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002663221 (1) | 4901 nt | ||
| Genomic | RefSeq:NW_018394741 (1) | 240229 nt | ||
| Polypeptide | UniProtKB:A0A286Y999 (1) | 1498 aa |
- Zheng, L., Cao, L., Zheng, X.L. (2022) ADAMTS13 protease or lack of von Willebrand factor protects irradiation and melanoma-induced thrombotic microangiopathy in zebrafish. Journal of thrombosis and haemostasis : JTH. 20(10):2270-2283
- Zheng, L., Hill, J., Zheng, L., Rumi, M.A.K., Zheng, X.L. (2022) A Simple, Robust, and Cost-effective Method for Genotyping Small-scale Mutations. Journal of clinical and translational pathology. 2:108-115
- Qiu, W., Fang, M., Magnuson, J.T., Greer, J.B., Chen, Q., Zheng, Y., Xiong, Y., Luo, S., Zheng, C., Schlenk, D. (2020) Maternal exposure to environmental antibiotic mixture during gravid period predicts gastrointestinal effects in zebrafish offspring. Journal of hazardous materials. 399:123009
- Zheng, L., Abdelgawwad, M.S., Zhang, D., Xu, L., Wei, S., Cao, W., Zheng, X.L. (2019) Histone-induced thrombotic thrombocytopenic purpura in adamts13-/- zebrafish depends on von Willebrand factor. Haematologica. 105(4):1107-1119
- Brunet, F.G., Fraser, F.W., Binder, M.J., Smith, A.D., Kintakas, C., Dancevic, C.M., Ward, A.C., McCulloch, D.R. (2015) The evolutionary conservation of the A Disintegrin-like and Metalloproteinase domain with Thrombospondin-1 motif metzincins across vertebrate species and their expression in teleost zebrafish. BMC Evolutionary Biology. 15:22
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Petrey, A.C., Flanagan-Steet, H., Johnson, S., Fan, X., De la Rosa, M., Haskins, M.E., Nairn, A.V., Moremen, K.W., and Steet, R. (2012) Excessive activity of cathepsin K is associated with the cartilage defects in a zebrafish model for mucolipidosis II. Disease models & mechanisms. 5(2):177-190
- Huxley-Jones, J., Clarke, T.K., Beck, C., Toubaris, G., Robertson, D.L., and Boot-Handford, R.P. (2007) The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. BMC Evolutionary Biology. 7(1):63
1 - 8 of 8
Show