Gene

adam22

ID

ZDB-GENE-070810-1

Name

ADAM metallopeptidase domain 22

Symbol

adam22 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 61. Orthologous to human ADAM22 (ADAM metallopeptidase domain 22).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adam22 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 61	Alliance	Developmental and epileptic encephalopathy 61	617933

Associated With adam22 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018358	Disintegrin, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001590	Peptidase M12B, ADAM/reprolysin
Domain	IPR001762	Disintegrin domain
Domain	IPR002870	Peptidase M12B, propeptide
Domain	IPR006586	ADAM, cysteine-rich domain
Domain	IPR013111	EGF-like domain, extracellular
Domain	IPR034027	Reprolysin domain, adamalysin-type
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036436	Disintegrin domain superfamily

Domain Details Per Protein

Protein	Length	ADAM, cysteine-rich domain	Disintegrin, conserved site	Disintegrin domain	Disintegrin domain superfamily	EGF-like domain	EGF-like domain, extracellular	Metallopeptidase, catalytic domain superfamily	Peptidase M12B, ADAM/reprolysin	Peptidase M12B, propeptide	Reprolysin domain, adamalysin-type
UniProtKB:A0A8M3AJF6 InterPro	949
UniProtKB:A0A8M9P8I9 InterPro	871
UniProtKB:A0A8M9PDU9 InterPro	978
UniProtKB:F1QF43 InterPro	918
UniProtKB:A0A8M3ATT0 InterPro	737

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	adam22-201 (1) Ensembl	Ensembl	4,159 nt	Select Tool
mRNA	adam22-202 (1) Ensembl	Ensembl	1,440 nt	Select Tool
mRNA	adam22-203 (1) Ensembl	Ensembl	1,561 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations