Gene
adam8b
- ID
- ZDB-GENE-070808-1
- Name
- ADAM metallopeptidase domain 8b
- Symbol
- adam8b Nomenclature History
- Previous Names
-
- CD156b
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable cell adhesion molecule binding activity and metallopeptidase activity. Predicted to be involved in several processes, including inflammatory response; positive regulation of cellular extravasation; and positive regulation of membrane protein ectodomain proteolysis. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Is expressed in ovarian follicle. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018358 | Disintegrin, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
| Domain | IPR001762 | Disintegrin domain |
| Domain | IPR002870 | Peptidase M12B, propeptide |
| Domain | IPR006586 | ADAM, cysteine-rich domain |
| Domain | IPR013111 | EGF-like domain, extracellular |
| Domain | IPR034027 | Reprolysin domain, adamalysin-type |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036436 | Disintegrin domain superfamily |
Domain Details Per Protein
| Protein | Length | ADAM, cysteine-rich domain | Disintegrin, conserved site | Disintegrin domain | Disintegrin domain superfamily | EGF-like domain | EGF-like domain, extracellular | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | Reprolysin domain, adamalysin-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AY73
|
794 | ||||||||||
|
UniProtKB:E7F6J8
|
819 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adam8b-201
(1)
|
Ensembl | 3,402 nt | ||
| mRNA |
adam8b-202
(1)
|
Ensembl | 741 nt |
Interactions and Pathways
No data available
Plasmids
No data available