Gene

jak3

ID

ZDB-GENE-070725-4

Name

Janus kinase 3 (a protein tyrosine kinase, leukocyte)

Symbol

jak3 Nomenclature History

Previous Names

sb:eu418

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable cytokine receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within T cell differentiation in thymus and natural killer cell differentiation. Predicted to be located in cytoskeleton and membrane. Predicted to be active in cytosol. Is expressed in male organism and thymus. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and severe combined immunodeficiency. Orthologous to human JAK3 (Janus kinase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu418 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With jak3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
janus kinase-3 deficiency	Alliance	Severe combined immunodeficiency, autosomal recessive, T-negative/B-positive type	600802

Associated With jak3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
severe combined immunodeficiency	jak3^mdu9/mdu9	standard conditions	Basheer et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000299	FERM domain
Domain	IPR000719	Protein kinase domain
Domain	IPR000980	SH2 domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR041046	JAK, FERM F2 lobe domain
Domain	IPR041155	FERM F1 lobe ubiquitin-like domain
Domain	IPR041381	JAK1-3/TYK2, pleckstrin homology-like domain
Family	IPR016251	Tyrosine-protein kinase, non-receptor Jak/Tyk2
Family	IPR051286	Janus Kinase (JAK)
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Length	Band 4.1 domain	FERM central domain	FERM domain	FERM F1 lobe ubiquitin-like domain	JAK1-3/TYK2, pleckstrin homology-like domain	JAK, FERM F2 lobe domain	Janus Kinase (JAK)	PH-like domain superfamily	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	SH2 domain	SH2 domain superfamily	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, non-receptor Jak/Tyk2
UniProtKB:B0V237 InterPro	1103

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	jak3-201 (1) Ensembl	Ensembl	3,410 nt	Select Tool ZFIN BLAST
mRNA	jak3-203 (1) Ensembl	Ensembl	3,312 nt	Select Tool ZFIN BLAST
mRNA	jak3-204 (1) Ensembl	Ensembl	3,258 nt	Select Tool ZFIN BLAST
ncRNA	jak3-002 (1) Ensembl	Ensembl	563 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations