Gene

myhz1.2

ID

ZDB-GENE-070705-73

Name

myosin, heavy polypeptide 1.2, skeletal muscle

Symbol

myhz1.2 Nomenclature History

Previous Names

fmyhc1.2 (1)
ns:zf-e523
si:ch211-158m24.8

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in muscle contraction. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in cephalic musculature and trunk. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; disease of cellular proliferation; distal arthrogryposis (multiple); and multiple pterygium syndrome. Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH4 (myosin heavy chain 4); and MYH8 (myosin heavy chain 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myhz1.2 Human Ortholog

No data available

Associated With myhz1.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002928	Myosin tail
Domain	IPR004009	Myosin, N-terminal, SH3-like
Homologous_superfamily	IPR008989	Myosin S1 fragment, N-terminal
Homologous_superfamily	IPR014751	DNA repair protein XRCC4-like, C-terminal
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily