Gene
opn4xb
- ID
- ZDB-GENE-070705-526
- Name
- opsin 4xb
- Symbol
- opn4xb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and phototransduction. Predicted to act upstream of or within signal transduction and visual perception. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including endocrine system; heart; integument; liver; and visual system.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf3569 | Allele with one deletion | Exon 2 | Premature Stop | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-opn4xb | N/A | Kokel et al., 2013 |
| TALEN1-opn4xb | Dekens et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G-protein coupled receptor opsins | G protein-coupled receptor, rhodopsin-like | Opsin | Visual pigments (opsins) retinal binding site |
|---|---|---|---|---|---|---|
|
UniProtKB:G8Z413
|
460 | |||||
|
UniProtKB:A0A8M9PKE3
|
408 | |||||
|
UniProtKB:A0A8M9PXW6
|
395 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
opn4xb-201
(1)
|
Ensembl | 1,383 nt | ||
| mRNA |
opn4xb-202
(1)
|
Ensembl | 2,008 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-100D11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001258223 (1) | 1383 nt | ||
| Genomic | GenBank:CT737133 (2) | 190674 nt | ||
| Polypeptide | UniProtKB:G8Z413 (1) | 460 aa |
No data available
- Dekens, M.P.S., Fontinha, B.M., Gallach, M., Pflügler, S., Tessmar-Raible, K. (2022) Melanopsin elevates locomotor activity during the wake state of the diurnal zebrafish. EMBO reports. 23(5):e51528
- Liang, Q., Afriyie, G., Chen, Z., Xu, Z., Dong, Z., Wang, Z., Guo, Y. (2021) Analysis of Opsin Gene Family of Crimson Snapper (Lutjanus erythropterus). Gene. 807:145960
- Qian, L., Qi, S., Wang, Z., Magnuson, J.T., Volz, D.C., Schlenk, D., Jiang, J., Wang, C. (2020) Environmentally relevant concentrations of boscalid exposure affects the neurobehavioral response of zebrafish by disrupting visual and nervous systems. Journal of hazardous materials. 404:124083
- Steindal, I.A.F., Whitmore, D. (2020) Zebrafish Circadian Clock Entrainment and the Importance of Broad Spectral Light Sensitivity. Frontiers in Physiology. 11:1002
- Davies, W.I., Tamai, T.K., Zheng, L., Fu, J.K., Rihel, J., Foster, R.G., Whitmore, D., Hankins, M.W. (2015) An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function. Genome research. 25(11):1666-79
- Blasic, J.R., Matos-Cruz, V., Ujla, D., Cameron, E.G., Hattar, S., Halpern, M.E., Robinson, P.R. (2014) Identification of critical phosphorylation sites on the carboxy tail of melanopsin. Biochemistry. 53:2644-9
- Backfisch, B., Veedin Rajan, V.B., Fischer, R.M., Lohs, C., Arboleda, E., Tessmar-Raible, K., and Raible, F. (2013) Stable transgenesis in the marine annelid Platynereis dumerilii sheds new light on photoreceptor evolution. Proceedings of the National Academy of Sciences of the United States of America. 110(1):193-198
- Kokel, D., Dunn, T.W., Ahrens, M.B., Alshut, R., Cheung, C.Y., Saint-Amant, L., Bruni, G., Mateus, R., van Ham, T.J., Shiraki, T., Fukada, Y., Kojima, D., Yeh, J.R., Mikut, R., von Lintig, J., Engert, F., and Peterson, R.T. (2013) Identification of Nonvisual Photomotor Response Cells in the Vertebrate Hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(9):3834-3843
- Davies, W.I., Zheng, L., Hughes, S., Tamai, T.K., Turton, M., Halford, S., Foster, R.G., Whitmore, D., and Hankins, M.W. (2011) Functional diversity of melanopsins and their global expression in the teleost retina. Cellular and molecular life sciences : CMLS. 68(24):4115-32
- Matos-Cruz, V., Blasic, J., Nickle, B., Robinson, P.R., Hattar, S., and Halpern, M.E. (2011) Unexpected diversity and photoperiod dependence of the zebrafish melanopsin system. PLoS One. 6(9):e25111
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