Gene
tmtc1
- ID
- ZDB-GENE-070705-219
- Name
- transmembrane O-mannosyltransferase targeting cadherins 1
- Symbol
- tmtc1 Nomenclature History
- Previous Names
-
- si:ch73-1o10.3
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable mannosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum and membrane. Orthologous to human TMTC1 (transmembrane O-mannosyltransferase targeting cadherins 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a351 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| sa13541 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18061 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20209 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26220 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa26221 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33390 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Protein O-mannosyl-transferase TMTC, DUF1736 | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat | TMTC O-mannosyl-transferase |
|---|---|---|---|---|---|
|
UniProtKB:F1QF84
|
872 | ||||
|
UniProtKB:A0A8M9Q1D5
|
345 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-1O10 | ZFIN Curated Data | |
| Contained in | BAC | CH73-139J3 | ZFIN Curated Data | |
| Contained in | BAC | CH211-116I17 | ZFIN Curated Data | |
| Contained in | BAC | CH211-251O16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001921990 (1) | |||
| Genomic | GenBank:CR790375 (1) | 153499 nt | ||
| Polypeptide | UniProtKB:F1QF84 (1) | 872 aa |
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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