Gene
nol9
- ID
- ZDB-GENE-070629-1
- Name
- nucleolar protein 9
- Symbol
- nol9 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable polynucleotide 5'-hydroxyl-kinase activity. Acts upstream of or within several processes, including cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); definitive hemopoiesis; and digestive system development. Predicted to be active in nucleus. Is expressed in caudal hematopoietic tissue; liver; pancreas; and pharyngeal arch 3-7. Orthologous to human NOL9 (nucleolar protein 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Bielczyk-Maczyńska et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 9 figures from Bielczyk-Maczyńska et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1022 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9241 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24337 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43985 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| t24596 | unknown | Unknown | Unknown | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 | Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain |
|---|---|---|---|---|
|
UniProtKB:E7F654
|
713 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_691014 (1) | 2889 nt | ||
| Genomic | GenBank:CR376748 (2) | 233351 nt | ||
| Polypeptide | UniProtKB:E7F654 (1) | 713 aa |
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- O'Meara, C.P., Guerri, L., Lawir, D.F., Mateos, F., Iconomou, M., Iwanami, N., Soza-Ried, C., Sikora, K., Siamishi, I., Giorgetti, O., Peter, S., Schorpp, M., Boehm, T. (2021) Genetic landscape of T cells identifies synthetic lethality for T-ALL. Communications biology. 4:1201
- Bielczyk-Maczyńska, E., Lam Hung, L., Ferreira, L., Fleischmann, T., Weis, F., Fernández-Pevida, A., Harvey, S.A., Wali, N., Warren, A.J., Barroso, I., Stemple, D.L., Cvejic, A. (2015) The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish. PLoS Genetics. 11:e1005677
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
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