Gene
casp10
- ID
- ZDB-GENE-070608-2
- Name
- caspase 10, apoptosis-related cysteine peptidase
- Symbol
- casp10 Nomenclature History
- Previous Names
-
- casp8l2
- caspase-8b (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and apoptotic process. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome (multiple); breast cancer; endocrine gland cancer (multiple); non-Hodgkin lymphoma; and primary immunodeficiency disease. Is expressed in floor plate; intestinal bulb; muscle cell; and pharyngeal arch. Orthologous to several human genes including CASP10 (caspase 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Spead et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autoimmune lymphoproliferative syndrome type 2A | Alliance | Autoimmune lymphoproliferative syndrome, type II | 603909 |
non-Hodgkin lymphoma | Alliance | Lymphoma, non-Hodgkin, somatic | 605027 |
stomach cancer | Alliance | Gastric cancer, somatic | 613659 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR016129 | Peptidase family C14A, His active site |
Active_site | IPR033139 | Peptidase family C14A, cysteine active site |
Domain | IPR001309 | Peptidase C14, p20 domain |
Domain | IPR001875 | Death effector domain |
Domain | IPR002138 | Peptidase C14, caspase non-catalytic subunit p10 |
Domain | IPR011600 | Peptidase C14, caspase domain |
Domain | IPR015917 | Peptidase C14A, caspase catalytic domain |
Family | IPR051290 | CASP8 and FADD-like apoptosis regulator |
Homologous_superfamily | IPR011029 | Death-like domain superfamily |
Homologous_superfamily | IPR029030 | Caspase-like domain superfamily |
Domain Details Per Protein
Protein | Length | CASP8 and FADD-like apoptosis regulator | Caspase-like domain superfamily | Death effector domain | Death-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, caspase non-catalytic subunit p10 | Peptidase C14, p20 domain | Peptidase family C14A, cysteine active site | Peptidase family C14A, His active site |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:E7EXV8
|
520 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
casp8l2-202
(1)
|
Havana | 763 nt | |
mRNA |
casp8l2-203
(1)
|
Havana | 747 nt | |
mRNA |
casp10-201
(1)
|
Ensembl | 2061 nt | |
mRNA |
casp10-204
(1)
|
Ensembl | 2145 nt | |
mRNA |
casp10-205
(1)
|
Ensembl | 1672 nt |
Interactions and Pathways
No data available
Plasmids
No data available