Gene
casp10
- ID
- ZDB-GENE-070608-2
- Name
- caspase 10, apoptosis-related cysteine peptidase
- Symbol
- casp10 Nomenclature History
- Previous Names
-
- casp8l2
- caspase-8b (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway and death effector domain binding activity. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and apoptotic process. Predicted to act upstream of or within proteolysis and regulation of apoptotic process. Predicted to be active in cytoplasm. Is expressed in floor plate; intestinal bulb; muscle cell; and pharyngeal arch. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2A; non-Hodgkin lymphoma; and stomach cancer. Orthologous to human CASP10 (caspase 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autoimmune lymphoproliferative syndrome type 2A | Alliance | Autoimmune lymphoproliferative syndrome, type II | 603909 |
| non-Hodgkin lymphoma | Alliance | Lymphoma, non-Hodgkin, somatic | 605027 |
| stomach cancer | Alliance | Gastric cancer, somatic | 613659 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016129 | Peptidase family C14A, His active site |
| Active_site | IPR033139 | Peptidase family C14A, cysteine active site |
| Domain | IPR001309 | Peptidase C14, p20 domain |
| Domain | IPR001875 | Death effector domain |
| Domain | IPR002138 | Peptidase C14, caspase non-catalytic subunit p10 |
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Domain Details Per Protein
| Protein | Length | Caspase-like domain superfamily | Death effector domain | Death-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, caspase non-catalytic subunit p10 | Peptidase C14, p20 domain | Peptidase family C14A, cysteine active site | Peptidase family C14A, His active site |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7EXV8
|
520 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
casp8l2-202
(1)
|
Ensembl | 763 nt | ||
| mRNA |
casp8l2-203
(1)
|
Ensembl | 747 nt | ||
| mRNA |
casp10-201
(1)
|
Ensembl | 2,061 nt | ||
| mRNA |
casp10-204
(1)
|
Ensembl | 2,145 nt | ||
| mRNA |
casp10-205
(1)
|
Ensembl | 1,672 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-108H4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_680338 (1) | 2060 nt | ||
| Genomic | GenBank:FP102120 (2) | 82853 nt | ||
| Polypeptide | UniProtKB:E7EXV8 (1) | 520 aa |
- Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
- Xu, H., Jiang, Y., Li, S., Xie, L., Tao, Y.X., Li, Y. (2020) Zebrafish Oxr1a Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging. Genes. 11(10):
- Chen, M., Luo, Y., Xu, J., Chang, M.X., Liu, J.X. (2019) Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival. Frontiers in immunology. 10:2599
- Spead, O., Verreet, T., Donelson, C.J., Poulain, F.E. (2018) Characterization of the caspase family in zebrafish. PLoS One. 13:e0197966
- Zhao, J., Huang, G., Xu, T., Yin, D., Bai, J., Gu, W. (2017) Early developmental exposure to pentachlorophenol causes alterations on mRNA expressions of caspase protease family in zebrafish embryos. Chemosphere. 180:141-148
- Zhou, Z.J., Sun, L. (2016) Edwardsiella tarda-Induced Inhibition of Apoptosis: A Strategy for Intracellular Survival. Frontiers in cellular and infection microbiology. 6:76
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Sakamaki, K., Iwabe, N., Iwata, H., Imai, K., Takagi, C., Chiba, K., Shukunami, C., Tomii, K., Ueno, N. (2015) Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change. Biochemistry and biophysics reports. 3:175-189
- Eimon, P.M., Kratz, E., Varfolomeev, E., Hymowitz, S.G., Stern, H., Zha, J., and Ashkenazi, A. (2006) Delineation of the cell-extrinsic apoptosis pathway in the zebrafish. Cell death and differentiation. 13(10):1619-1630
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