Gene
ghra
- ID
- ZDB-GENE-070509-1
- Name
- growth hormone receptor a
- Symbol
- ghra Nomenclature History
- Previous Names
-
- ghr
- zgc:162141
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including growth factor binding activity; growth hormone receptor activity; and peptide hormone binding activity. Predicted to be involved in cell surface receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within endocytosis. Predicted to be located in plasma membrane. Predicted to be part of growth hormone receptor complex. Predicted to be active in cytosol and external side of plasma membrane. Is expressed in several structures, including lens; liver; notochord; pleuroperitoneal region; and yolk. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hypercholesterolemia | Alliance | {Hypercholesterolemia, familial, modifier of} | 143890 |
| Laron syndrome | Alliance | Laron dwarfism | 262500 |
| Growth hormone insensitivity, partial | 604271 | ||
| Increased responsiveness to growth hormone | 604271 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003528 | Long hematopoietin receptor, single chain, conserved site |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR015152 | Growth hormone/erythropoietin receptor, ligand binding |
| Domain | IPR025871 | Growth hormone-binding protein |
| Family | IPR050379 | Type I Cytokine Receptor |
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Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Growth hormone-binding protein | Growth hormone/erythropoietin receptor, ligand binding | Immunoglobulin-like fold | Long hematopoietin receptor, single chain, conserved site | Type I Cytokine Receptor |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A4IG30
|
570 |
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Interactions and Pathways
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-194C22 | ||
| Contained in | BAC | CH211-226F24 | ||
| Contained in | BAC | DKEY-46A10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162141 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001083578 (1) | 2269 nt | ||
| Genomic | GenBank:CR352327 (1) | 203325 nt | ||
| Polypeptide | UniProtKB:A4IG30 (1) | 570 aa |
- Ni, Y., Zhang, Y., Zheng, L., Rong, N., Yang, Y., Gong, P., Yang, Y., Siwu, X., Zhang, C., Zhu, L., Fu, Z. (2023) Bifidobacterium and Lactobacillus improve inflammatory bowel disease in zebrafish of different ages by regulating the intestinal mucosal barrier and microbiota. Life sciences. 324:121699
- Wei, Z., Bagivalu Lakshminarasimha, A., Cone, R., Michel, M. (2023) Loss of Agrp1 in zebrafish: Effects on the growth and reproductive axis. General and comparative endocrinology. 336:114243
- Dong, X.R., Wan, S.M., Zhou, J.J., Nie, C.H., Chen, Y.L., Diao, J.H., Gao, Z.X. (2022) Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Frontiers in cell and developmental biology. 10:838721
- Morgan, R., Andreassen, A.H., Åsheim, E.R., Finnøen, M.H., Dresler, G., Brembu, T., Loh, A., Miest, J.J., Jutfelt, F. (2022) Reduced physiological plasticity in a fish adapted to stable temperatures. Proceedings of the National Academy of Sciences of the United States of America. 119:e2201919119
- Panaro, M.A., Calvello, R., Miniero, D.V., Mitolo, V., Cianciulli, A. (2022) Imaging Intron Evolution. Methods and protocols. 5(4):
- Zhao, T., Ye, Z., Liu, Y., Lin, H., Li, S., Zhang, Y. (2022) Mutation of spexin2 promotes feeding, somatic growth, adiposity and insulin resistance in zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 322(5):R454-R465
- Zhou, W., Wang, Y., Wang, J., Peng, C., Wang, Z., Qin, H., Li, G., Li, D. (2022) β-Ionone causes endocrine disruption, hyperpigmentation and hypoactivity in zebrafish early life stages. The Science of the total environment. 834:155433
- Liu, X., Xie, X., Liu, H. (2021) Effects of Diethylstilbestrol on Zebrafish Gonad Development and Endocrine Disruption Mechanism. Biomolecules. 11(7):
- Lutfi, E., Basili, D., Falcinelli, S., Morillas, L., Carnevali, O., Capilla, E., Navarro, I. (2021) The probiotic Lactobacillus rhamnosus mimics the dark-driven regulation of appetite markers and melatonin receptors' expression in zebrafish (Danio rerio) larvae: Understanding the role of the gut microbiome. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 256:110634
- Meirelles, M.G., Nornberg, B.F., da Silveira, T.L.R., Kütter, M.T., Castro, C.G., Ramirez, J.R.B., Pedrosa, V., Romano, L.A., Marins, L.F. (2021) Growth Hormone Overexpression Induces Hyperphagia and Intestinal Morphophysiological Adaptations to Improve Nutrient Uptake in Zebrafish. Frontiers in Physiology. 12:723853
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