Gene
dpys
- ID
- ZDB-GENE-070508-1
- Name
- dihydropyrimidinase
- Symbol
- dpys Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have dihydropyrimidinase activity. Predicted to be involved in pyrimidine nucleobase catabolic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in dihydropyrimidinase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human DPYS (dihydropyrimidinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Takada et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dihydropyrimidinase deficiency | Alliance | Dihydropyrimidinuria | 222748 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006680 | Amidohydrolase-related |
| Family | IPR011778 | Hydantoinase/dihydropyrimidinase |
| Family | IPR050378 | Metallo-dependent Hydrolases Superfamily |
| Homologous_superfamily | IPR011059 | Metal-dependent hydrolase, composite domain superfamily |
| Homologous_superfamily | IPR032466 | Metal-dependent hydrolase |
Domain Details Per Protein
| Protein | Length | Amidohydrolase-related | Hydantoinase/dihydropyrimidinase | Metal-dependent hydrolase | Metal-dependent hydrolase, composite domain superfamily | Metallo-dependent Hydrolases Superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:B1H1J6
|
500 |
Interactions and Pathways
No data available
Plasmids
No data available