Gene
septin8b
- ID
- ZDB-GENE-070424-3
- Name
- septin 8b
- Symbol
- septin8b Nomenclature History
- Previous Names
-
- sept8b
- zgc:136574 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Is expressed in nervous system. Orthologous to human SEPTIN8 (septin 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Septin | Septin-type guanine nucleotide-binding (G) domain |
|---|---|---|---|---|
|
UniProtKB:A0A8M9QP77
|
410 | |||
|
UniProtKB:A4FUM1
|
423 | |||
|
UniProtKB:A0A8M2BGW7
|
445 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
sept8b-202
(1)
|
Ensembl | 622 nt | ||
| mRNA |
sept8b-201
(1)
|
Ensembl | 1,924 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-121D2 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136574 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001083566 (1) | 1451 nt | ||
| Genomic | GenBank:CR855307 (1) | 167962 nt | ||
| Polypeptide | UniProtKB:A0A8M2BGW7 (1) | 445 aa |
- Torraca, V., Bielecka, M.K., Gomes, M.C., Brokatzky, D., Busch-Nentwich, E.M., Mostowy, S. (2023) Zebrafish null mutants of Sept6 and Sept15 are viable but susceptible to Shigella infection. Cytoskeleton (Hoboken, N.J.). 80(7-8):266-274
- Mitchell, D.M., Sun, C., Hunter, S.S., New, D.D., Stenkamp, D.L. (2019) Regeneration associated transcriptional signature of retinal microglia and macrophages. Scientific Reports. 9:4768
- Sun, C., Galicia, C., Stenkamp, D.L. (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics. 19:127
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Berger, C., Helmprobst, F., Chapouton, P., Lillesaar, C., Stigloher, C. (2017) sept8a and sept8b mRNA expression in the developing and adult zebrafish. Gene expression patterns : GEP. 25-26:8-21
- Lee, S.L.J., Horsfield, J.A., Black, M.A., Rutherford, K., Fisher, A., Gemmell, N.J. (2017) Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics. 18:557
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Groh, K.J., Schoenenberger, R., Eggen, R.I., Segner, H., and Suter, M.J. (2013) Analysis of protein expression in zebrafish during gonad differentiation by targeted proteomics. General and comparative endocrinology. 193:210-20
- Cao, L., Ding, X., Yu, W., Yang, X., Shen, S., and Yu, L. (2007) Phylogenetic and evolutionary analysis of the septin protein family in metazoan. FEBS letters. 581(28):5526-5532
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