Gene
klf8
- ID
- ZDB-GENE-070424-152
- Name
- Kruppel like factor 8
- Symbol
- klf8 Nomenclature History
- Previous Names
-
- si:ch211-208m1.2
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cerebellar Purkinje cell differentiation; cerebellar granule cell differentiation; and establishment of left/right asymmetry. Is expressed in several structures, including brain; digestive system; optic cup; optic vesicle; and retina. Orthologous to human KLF8 (KLF transcription factor 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Tsai et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|
|
UniProtKB:A0A8M2BHN8
|
316 | ||
|
UniProtKB:A0S0R1
|
343 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-38K9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194487 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194489 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080003 (1) | 3813 nt | ||
| Genomic | GenBank:BX530030 (1) | 180154 nt | ||
| Polypeptide | UniProtKB:A0S0R1 (1) | 343 aa |
- Huang, L., Urasaki, A., Inagaki, N. (2019) Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain. Scientific Reports. 9:1799
- Lin, C.Y., Tsai, M.Y., Liu, Y.H., Lu, Y.F., Chen, Y.C., Lai, Y.R., Liao, H.C., Lien, H.W., Yang, C.H., Huang, C.J., Hwang, S.L. (2017) Klf8 regulates left-right asymmetric patterning through modulation of Kupffer's vesicle morphogenesis and spaw expression. Journal of Biomedical Science. 24:45
- Shao, M., Ge, G.Z., Liu, W.J., Xiao, J., Xia, H.J., Fan, Y., Zhao, F., He, B.L., Chen, C. (2017) Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis). Oncotarget. 8(10):16325-16339
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Tsai, M., Lu, Y., Liu, Y., Lien, H., Huang, C., Wu, J., Hwang, S.L. (2015) Modulation of p53 and met expression by krüppel-like factor 8 regulates zebrafish cerebellar development. Developmental Neurobiology. 75(9):908-26
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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