Gene
micu1
- ID
- ZDB-GENE-070410-22
- Name
- mitochondrial calcium uptake 1
- Symbol
- micu1 Nomenclature History
- Previous Names
-
- zgc:162148 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Predicted to be involved in calcium import into the mitochondrion; calcium ion import; and positive regulation of mitochondrial calcium ion concentration. Predicted to act upstream of or within calcium ion transport. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of uniplex complex. Is expressed in female organism; heart; and heart tube. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Soman et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myopathy with extrapyramidal signs | Alliance | Myopathy with extrapyramidal signs | 615673 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calcium uptake protein 1/2/3 | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair |
|---|---|---|---|---|---|
|
UniProtKB:E9QGA3
|
485 | ||||
|
UniProtKB:A0A8M3B503
|
487 | ||||
|
UniProtKB:A0A8M2B2M2
|
491 | ||||
|
UniProtKB:A4IG32
|
489 |
Interactions and Pathways
No data available
Plasmids