Gene
setx
- ID
- ZDB-GENE-070402-1
- Name
- senataxin
- Symbol
- setx Nomenclature History
- Previous Names
-
- wu:fj92h09
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have RNA binding activity and transcription termination site sequence-specific DNA binding activity. Predicted to be involved in termination of RNA polymerase II transcription. Predicted to localize to nuclear body. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 4 and ataxia with oculomotor apraxia type 2. Orthologous to human SETX (senataxin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Laboissonniere et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 4 | Alliance | Amyotrophic lateral sclerosis 4, juvenile | 602433 |
| spinocerebellar ataxia with axonal neuropathy 2 | Alliance | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 | 606002 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR024481 | Helicase Sen1, N-terminal |
| Domain | IPR041677 | DNA2/NAM7 helicase, helicase domain |
| Domain | IPR041679 | DNA2/NAM7 helicase-like, C-terminal |
| Domain | IPR047187 | Upf1-like, C-terminal helicase domain |
| Family | IPR045055 | DNA2/NAM7-like helicase |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | Armadillo-type fold | DNA2/NAM7 helicase, helicase domain | DNA2/NAM7 helicase-like, C-terminal | DNA2/NAM7-like helicase | Helicase Sen1, N-terminal | P-loop containing nucleoside triphosphate hydrolase | Upf1-like, C-terminal helicase domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7UR12
|
2368 | |||||||
|
UniProtKB:A0A8M3B4F2
|
2085 |
Interactions and Pathways
No data available
Plasmids
No data available