Gene

ncf2

ID
ZDB-GENE-070209-29
Name
neutrophil cytosolic factor 2
Symbol
ncf2 Nomenclature History
Previous Names
  • p67phox (1)
  • zgc:158405
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have Rac GTPase binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in superoxide anion generation. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal recessive chronic granulomatous disease cytochrome b-positive type II. Orthologous to human NCF2 (neutrophil cytosolic factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ncf2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive chronic granulomatous disease 2 Alliance Chronic granulomatous disease 2, autosomal recessive 233710
Associated With ncf2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001452 SH3 domain
Domain IPR034885 Neutrophil cytosol factor 2, PB1 domain
Domain IPR034889 Neutrophil cytosol factor 2, SH3 domain
Domain IPR035546 Neutrophil cytosol factor 2, SH3 domain 1
Family IPR051864 NADPH Oxidase Activator
Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Repeat IPR019734 Tetratricopeptide repeat
Domain Details Per Protein
Protein Length NADPH Oxidase Activator Neutrophil cytosol factor 2, PB1 domain Neutrophil cytosol factor 2, SH3 domain Neutrophil cytosol factor 2, SH3 domain 1 SH3 domain SH3-like domain superfamily Tetratricopeptide-like helical domain superfamily Tetratricopeptide repeat
UniProtKB:A2VCY2 500
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ncf2-201 (1) Ensembl 3,407 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations