Gene
vcam1b
- ID
- ZDB-GENE-070209-238
- Name
- vascular cell adhesion molecule 1b
- Symbol
- vcam1b Nomenclature History
- Previous Names
-
- vcam1
- fi76d06
- wu:fi76d06
- zgc:158875 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Acts upstream of or within lymphangiogenesis. Predicted to be located in membrane. Is expressed in several structures, including basal plate midbrain region; cardiovascular system; central nervous system; periderm; and trunk. Human ortholog(s) of this gene implicated in gastrointestinal system disease and hypertension. Orthologous to human VCAM1 (vascular cell adhesion molecule 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d127 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Li et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cas011 | Allele with one deletion | Exon 4 | Unknown | CRISPR | |
| sa9939 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa10702 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24124 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31070 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45764 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like beta-sandwich domain | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Intercellular adhesion molecule/vascular cell adhesion molecule | Vascular cell adhesion molecule-1 |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A5PMX0
|
808 | |||||||||
|
UniProtKB:A4JYI2
|
808 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
vcam1b-201
(1)
|
Ensembl | 3,475 nt | ||
| mRNA |
vcam1b-202
(1)
|
Ensembl | 5,261 nt | ||
| mRNA |
vcam1b-203
(1)
|
Ensembl | 5,522 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-190N7 | ZFIN Curated Data | |
| Encodes | EST | fi76d06 | ||
| Encodes | cDNA | cssl:d127 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:158875 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001083835 (1) | 3460 nt | ||
| Genomic | GenBank:BX908733 (1) | 134155 nt | ||
| Polypeptide | UniProtKB:A4JYI2 (1) | 808 aa |
- Domingues, N., Gaifem, J., Matthiesen, R., Saraiva, D.P., Bento, L., Marques, A.R.A., Soares, M.I.L., Sampaio, J., Klose, C., Surma, M.A., Almeida, M.S., Rodrigues, G., Gonçalves, P.A., Ferreira, J., E Melo, R.G., Pedro, L.M., Simons, K., Pinho E Melo, T.M.V.D., Cabral, M.G., Jacinto, A., Silvestre, R., Vaz, W., Vieira, O.V. (2023) Cholesteryl hemiazelate Identified in Cardiovascular Disease Patients Causes in vitro and in vivo Inflammation. Journal of Lipid Research. 64(9):100419
- Hipke, K., Pitter, B., Hruscha, A., van Bebber, F., Modic, M., Bansal, V., Lewandowski, S.A., Orozco, D., Edbauer, D., Bonn, S., Haass, C., Pohl, U., Montanez, E., Schmid, B. (2023) Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1. Frontiers in cell and developmental biology. 11:11699621169962
- Kondo, M., Kimura, K., Kobayashi-Sun, J., Yamamori, S., Taniguchi, M., Traver, D., Kobayashi, I. (2023) The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney. iScience. 26:106508106508
- Lazzaroni, F., Meessen, J.M.T.A., Sun, Y., Lanfranconi, S., Scola, E., D'Alessandris, Q.G., Tassi, L., Carriero, M.R., Castori, M., Marino, S., Blanda, A., Nicolis, E.B., Novelli, D., Calabrese, R., Agnelli, N.M., Bottazzi, B., Leone, R., Mazzola, S., Besana, S., Catozzi, C., Nezi, L., Lampugnani, M.G., Malinverno, M., Grdseloff, N., Rödel, C.J., Rezai Jahromi, B., Bolli, N., Passamonti, F., Magnusson, P.U., Abdelilah-Seyfried, S., Dejana, E., Latini, R. (2023) Circulating biomarkers in familial cerebral cavernous malformation. EBioMedicine. 99:104914104914
- Han, J., Zhang, R., Zhang, X., Dong, J., Chen, M., Pan, Y., Liao, Z., Zhong, M., He, J., Wang, F., Yue, Y., Shang, J. (2021) Zebrafish Model for Screening Antiatherosclerosis Drugs. Oxidative medicine and cellular longevity. 2021:9995401
- Hang, N.T., Nachtergael, A., Mai, N.T., Cornet, V., Duez, P., Muller, M., Ly Huong, D.T., Kestemont, P. (2020) Anti-inflammatory properties of the ethanol extract from Clerodendrum cyrtophyllum Turcz based on in vitro and in vivo studies. Journal of ethnopharmacology. 254:112739
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Li, D., Xue, W., Li, M., Dong, M., Wang, J., Wang, X., Li, X., Chen, K., Zhang, W., Wu, S., Zhang, Y., Gao, L., Chen, Y., Chen, J., Zhou, B.O., Zhou, Y., Yao, X., Li, L., Wu, D., Pan, W. (2018) VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche. Nature. 564(7734):119-124
- Yang, Y., Enis, D., Zheng, H., Chia, S., Yang, J., Chen, M., Dhillon, V., Papayannapoulou, T., Kahn, M.L. (2015) Cell Adhesion Mediated by VCAM-ITGa9 Interactions Enables Lymphatic Development. Arterioscler. Thromb. Vasc. Biol.. 35(5):1179-89
- Sukardi, H., Zhang, X., Lui, E.Y., Ung, C.Y., Mathavan, S., Gong, Z., and Lam, S.H. (2012) Liver X receptor agonist T0901317 induced liver perturbation in zebrafish: Histological, gene set enrichment and expression analyses. Biochimica et biophysica acta. General subjects. 1820(1):33-43
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