Gene
dgkb
- ID
- ZDB-GENE-070126-1
- Name
- diacylglycerol kinase, beta
- Symbol
- dgkb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable diacylglycerol kinase activity. Predicted to be involved in diacylglycerol metabolic process; intracellular signal transduction; and lipid phosphorylation. Predicted to act upstream of or within phosphorylation and protein kinase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human DGKB (diacylglycerol kinase beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from O'Hare et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa13600 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 1 of 1
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR000756 | Diacylglycerol kinase, accessory domain |
| Domain | IPR001206 | Diacylglycerol kinase, catalytic domain |
| Domain | IPR002048 | EF-hand domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
1 - 5 of 14 Show all
Domain Details Per Protein
| Protein | Length | C1-like domain superfamily | DGK type I, N-terminal domain superfamily | Diacylglycerol kinase | Diacylglycerol kinase, accessory domain | Diacylglycerol kinase beta-like, first protein kinase C conserved region 1 | Diacylglycerol kinase beta, second protein kinase C conserved region 1 | Diacylglycerol kinase, catalytic domain | Diacylglycerol kinase type I, N-terminal | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Inorganic polyphosphate/ATP-NAD kinase, N-terminal | NAD kinase/diacylglycerol kinase-like domain superfamily | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P7J8
|
786 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-146K18 | ZFIN Curated Data | |
| Contained in | BAC | CH211-219C8 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021466523 (1) | 3526 nt | ||
| Genomic | GenBank:BX470068 (1) | 210511 nt | ||
| Polypeptide | UniProtKB:A0A8M9P7J8 (1) | 786 aa |
- Comparative Orthology
- Alliance
- Franklin, C., Dwyer, D.S. (2020) Candidate Risk Genes for Bipolar Disorder are Highly Conserved during Evolution and Highly Interconnected. Bipolar disorders. 23(4):400-408
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45
- Sivasubbu, S., Balciunas, D., Davidson, A.E., Pickart, M.A., Hermanson, S.B., Wangensteen, K.J., Wolbrink, D.C., and Ekker, S.C. (2006) Gene-breaking transposon mutagenesis reveals an essential role for histone H2afza in zebrafish larval development. Mechanisms of Development. 123(7):513-529
1 - 4 of 4
Show