Gene
edar
- ID
- ZDB-GENE-070117-2062
- Name
- ectodysplasin A receptor
- Symbol
- edar Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Acts upstream of or within dermal bone morphogenesis; feeding behavior; and fin development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including epidermal cell; integument; mouth; pectoral fin skeleton; and pelvic fin bud. Human ortholog(s) of this gene implicated in ectodermal dysplasia 10A and ectodermal dysplasia 10B. Orthologous to human EDAR (ectodysplasin A receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ectodermal dysplasia 10A | Alliance | Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant | 129490 |
| ectodermal dysplasia 10B | Alliance | Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive | 224900 |
| [Hair morphology 1, hair thickness] | 612630 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Death-like domain superfamily | Tumor necrosis factor receptor EDAR, N-terminal | Tumor necrosis factor receptor superfamily member 19/27/EDAR |
|---|---|---|---|---|
|
UniProtKB:A0A0R4IGE7
|
460 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available