Gene
ptgis
- ID
- ZDB-GENE-070116-1
- Name
- prostaglandin I2 (prostacyclin) synthase
- Symbol
- ptgis Nomenclature History
- Previous Names
-
- ptgisl
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables heme binding activity and prostaglandin-I synthase activity. Involved in prostaglandin biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in colorectal adenoma; essential hypertension; and hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yeh et al., 2006
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential hypertension | Alliance | Hypertension, essential | 145500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, cholesterol 7-alpha-monooxygenase-type | Cytochrome P450, E-class, group IV | Cytochrome P450 superfamily |
|---|---|---|---|---|---|
|
UniProtKB:F1RE08
|
480 |
Interactions and Pathways
No data available
Plasmids
No data available