Gene

ogg1

ID

ZDB-GENE-070112-932

Name

8-oxoguanine DNA glycosylase

Symbol

ogg1 Nomenclature History

Previous Names

zgc:158858

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity. Involved in animal organ development; negative regulation of neuron apoptotic process; and regulation of neuron projection development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; angiomyolipoma; carcinoma (multiple); eye disease (multiple); and reproductive organ cancer (multiple). Is expressed in several structures, including anterior lateral plate mesoderm; anterior presumptive neural plate; nervous system; pericardial region; and pronephric duct. Orthologous to human OGG1 (8-oxoguanine DNA glycosylase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ogg1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nonpapillary renal cell carcinoma	Alliance	Renal cell carcinoma, clear cell, somatic	144700

Associated With ogg1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003265	HhH-GPD domain
Domain	IPR012904	8-oxoguanine DNA glycosylase, N-terminal
Family	IPR052054	Oxidative DNA damage repair enzyme
Homologous_superfamily	IPR011257	DNA glycosylase
Homologous_superfamily	IPR023170	Helix-hairpin-helix, base-excision DNA repair, C-terminal